Vitamin D use and health outcomes after surgery for hip fracture

Sheila Sprague, Gerard P. Slobogean, Earl Bogoch, Brad Petrisor, Alisha Garibaldi, Nathan O'Hara, Mohit Bhandari, Marc Swiontkowski, P. J. Devereaux, Gordon Guyatt, Martin J. Heetveld, Kyle Jeray, Susan Liew, Martin Richardson, Emil H. Schemitsch, Lehana Thabane, Paul Tornetta, Stephen D. Walter, Paula McKay, Taryn ScottHelena Viveiros, Marilyn Swinton, Mark Gichuru, Sofia Bzovsky, Diane Heels-Ansdell, Qi Zhou, Lisa Buckingham, Aravin Duraikannan, Deborah Maddock, Nicole Simunovic, Julie Age, Esther M.M. Van Lieshout, Stephanie M. Zielinski, Amar Rangan, Birgit C. Hanusch, Lucksy Kottam, Rachel Clarkson, Gregory J. Della Rocca, Robert Haverlag, Robert McCormack, Kelly Apostle, Dory Boyer, Farhad Moola, Bertrand Perey, Trevor Stone, Darius Viskontas, H. Michael Lemke, Mauri Zomar, Karyn Moon, Sarah A Anderson, Raely Moon, FAITH Investigators

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Daily administration of vitamin D is important for maintaining bone homeostasis. The orthopedic community has shown increased interest in vitamin D supplementation and patient outcomes after fracture. The current study used data from a large hip fracture trial to determine the proportion of patients who consistently used vitamin D after hip fracture surgery and to determine whether supplementation was associated with improved health-related quality of life and reduced reoperation rates. The FAITH study is a multicenter trial of elderly patients with femoral neck fracture treated with internal fixation. The current study asked a subset of patients included in the FAITH study about vitamin D supplementation and categorized them as consistent users, inconsistent users, or nonusers. This study also evaluated whether supplementation was associated with improved quality of life and reduced reoperation rates. The final analysis included 573 patients (mean age, 74.1 years; female, 66.3%; nondisplaced fractures, 72.4%). A total of 18.7% of participants reported no use of vitamin D, 35.6% reported inconsistent use, and 45.7% reported consistent use. Adjusted analysis found that consistent supplementation was associated with a 2.42 increase of the Short Form-12 physical component score 12 months postoperatively (P=.033). However, supplementation was not associated with reduced reoperation rates (P=.386). Despite guidelines recommending vitamin D supplementation, a low proportion of elderly patients with hip fracture use vitamin D consistently, suggesting a need for additional strategies to promote compliance. This study found that the use of vitamin D was associated with a statistically significant but not clinically significant improvement in health-related quality of life after hip fracture. Further research is needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)e868-e875
Issue number5
StatePublished - Sep 1 2017

Bibliographical note

Funding Information:
The FAITH study was funded by the Canadian Institutes of Health Research, National Institutes of Health, Stichting NutsOhra, The Netherlands Organisation for Health Research and Development, and Physicians’ Services Incorporated. Funding for the pilot phase of FAITH was supported in part by Stryker. The FAITH Investigators are listed in Table A.


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