Vitamin D status among long-term survivors of hematopoietic cell transplantation

K. Robien, Lori S Strayer, N. Majhail, DeAnn Lazovich, K. S. Baker, Angela R Smith, D. A. Mulrooney, L. J. Burns

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Little is known about serum vitamin D levels following hematopoietic cell transplantation (HCT). Patients are instructed to avoid sun exposure because of an increased risk of skin cancers. Altered gastrointestinal absorptive capacity as a result of GVHD, bile acid or pancreatic enzyme insufficiency or bacterial overgrowth may lead to difficulty in absorbing the fat-soluble vitamin D. This study was undertaken to determine the prevalence of serum 25-hydroxyvitamin D (25(OH)D) deficiency, and factors associated with 25(OH)D deficiency, among children and adults who were at least 1 year following HCT. A total of 95 participants (54 males and 41 females) completed a questionnaire on usual diet and lifestyle, and provided a blood sample for 25(OH)D determinations between November 2008 and July 2009. The majority of participants had serum 25(OH)D levels ≥75 nmol/L (n=62, 65%), 23 had insufficient levels (50-75 nmol/L) and 10 participants were deficient (<50 nmol/L). The majority of participants reported regular use of vitamin D supplements (n=58, 61%). Prednisone use was significantly inversely associated with serum 25(OH)D concentrations. Total vitamin D intake was the strongest single predictor of 25(OH)D concentrations. These findings suggest that 400-600 IU vitamin D per day appears to be required to achieve optimal serum 25(OH)D concentrations following HCT.

Original languageEnglish (US)
Pages (from-to)1472-1479
Number of pages8
JournalBone marrow transplantation
Volume46
Issue number11
DOIs
StatePublished - Nov 1 2011

Keywords

  • cancer survivors
  • diet
  • dietary supplements
  • hematopoietic cell transplantation
  • serum 25(OH)D
  • vitamin D

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    Robien, K., Strayer, L. S., Majhail, N., Lazovich, D., Baker, K. S., Smith, A. R., Mulrooney, D. A., & Burns, L. J. (2011). Vitamin D status among long-term survivors of hematopoietic cell transplantation. Bone marrow transplantation, 46(11), 1472-1479. https://doi.org/10.1038/bmt.2010.326