Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis

Elizabeth M. Groth, Jody P Lulich, Dennis J. Chew, Valerie J. Parker, Eva Furrow

Research output: Contribution to journalArticle

Abstract

Background: There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis. Objective: To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis. Animals: Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria. Methods: Retrospective cross-sectional study. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) 2 D], and 24,25-dihydroxyvitamin D [24,25(OH) 2 D] were measured. The ratios of 25(OH)D/24,25(OH) 2 D and 1,25(OH) 2 D/25(OH)D were compared between cases and controls. Results: There were no significant differences between cases and controls when comparing 25(OH)D, 24,25(OH) 2 D, 1,25(OH) 2 D, or 1,25(OH) 2 D/25(OH)D. Cases had higher 25(OH)D/24,25(OH) 2 D (median = 1.40, range = 0.98-1.58) compared to controls (median = 1.16, range = 0.92-2.75; P =.01). There was overlap in the ranges for 25(OH)D/24,25(OH) 2 D between cases and controls, but 6 cases (32%) had ratios above the control dog range. There was a moderate positive correlation between the ratio of 25(OH)D/24,25(OH) 2 D and urinary calcium-to-creatinine ratios (r = 0.40, 95% confidence interval = 0.10-0.64; P =.01). Conclusions and Clinical Importance: These data suggest that decreased conversion of 25(OH)D to 24,25(OH) 2 D occurs in a subset of dogs with CaOx urolithiasis. Abnormalities in vitamin D metabolism might contribute to stone risk in dogs.

Original languageEnglish (US)
Pages (from-to)758-763
Number of pages6
JournalJournal of veterinary internal medicine
Volume33
Issue number2
DOIs
StatePublished - Mar 1 2019

Fingerprint

calcium oxalate
vitamin D
Vitamin D
Dogs
metabolism
dogs
renal calculi
Calcium
calcium
Hypercalciuria
Nephrolithiasis
Dihydroxycholecalciferols
Serum
cross-sectional studies
creatinine
urolithiasis
Calcium Oxalate Nephrolithiasis
confidence interval
Creatinine
Cross-Sectional Studies

Keywords

  • calcitriol
  • canine
  • hypercalciuria
  • stones

PubMed: MeSH publication types

  • Journal Article

Cite this

Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis. / Groth, Elizabeth M.; Lulich, Jody P; Chew, Dennis J.; Parker, Valerie J.; Furrow, Eva.

In: Journal of veterinary internal medicine, Vol. 33, No. 2, 01.03.2019, p. 758-763.

Research output: Contribution to journalArticle

@article{009fac7a5c5e4aeca4f9f19ecc0f5e60,
title = "Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis",
abstract = "Background: There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis. Objective: To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis. Animals: Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria. Methods: Retrospective cross-sectional study. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) 2 D], and 24,25-dihydroxyvitamin D [24,25(OH) 2 D] were measured. The ratios of 25(OH)D/24,25(OH) 2 D and 1,25(OH) 2 D/25(OH)D were compared between cases and controls. Results: There were no significant differences between cases and controls when comparing 25(OH)D, 24,25(OH) 2 D, 1,25(OH) 2 D, or 1,25(OH) 2 D/25(OH)D. Cases had higher 25(OH)D/24,25(OH) 2 D (median = 1.40, range = 0.98-1.58) compared to controls (median = 1.16, range = 0.92-2.75; P =.01). There was overlap in the ranges for 25(OH)D/24,25(OH) 2 D between cases and controls, but 6 cases (32{\%}) had ratios above the control dog range. There was a moderate positive correlation between the ratio of 25(OH)D/24,25(OH) 2 D and urinary calcium-to-creatinine ratios (r = 0.40, 95{\%} confidence interval = 0.10-0.64; P =.01). Conclusions and Clinical Importance: These data suggest that decreased conversion of 25(OH)D to 24,25(OH) 2 D occurs in a subset of dogs with CaOx urolithiasis. Abnormalities in vitamin D metabolism might contribute to stone risk in dogs.",
keywords = "calcitriol, canine, hypercalciuria, stones",
author = "Groth, {Elizabeth M.} and Lulich, {Jody P} and Chew, {Dennis J.} and Parker, {Valerie J.} and Eva Furrow",
year = "2019",
month = "3",
day = "1",
doi = "10.1111/jvim.15442",
language = "English (US)",
volume = "33",
pages = "758--763",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis

AU - Groth, Elizabeth M.

AU - Lulich, Jody P

AU - Chew, Dennis J.

AU - Parker, Valerie J.

AU - Furrow, Eva

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis. Objective: To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis. Animals: Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria. Methods: Retrospective cross-sectional study. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) 2 D], and 24,25-dihydroxyvitamin D [24,25(OH) 2 D] were measured. The ratios of 25(OH)D/24,25(OH) 2 D and 1,25(OH) 2 D/25(OH)D were compared between cases and controls. Results: There were no significant differences between cases and controls when comparing 25(OH)D, 24,25(OH) 2 D, 1,25(OH) 2 D, or 1,25(OH) 2 D/25(OH)D. Cases had higher 25(OH)D/24,25(OH) 2 D (median = 1.40, range = 0.98-1.58) compared to controls (median = 1.16, range = 0.92-2.75; P =.01). There was overlap in the ranges for 25(OH)D/24,25(OH) 2 D between cases and controls, but 6 cases (32%) had ratios above the control dog range. There was a moderate positive correlation between the ratio of 25(OH)D/24,25(OH) 2 D and urinary calcium-to-creatinine ratios (r = 0.40, 95% confidence interval = 0.10-0.64; P =.01). Conclusions and Clinical Importance: These data suggest that decreased conversion of 25(OH)D to 24,25(OH) 2 D occurs in a subset of dogs with CaOx urolithiasis. Abnormalities in vitamin D metabolism might contribute to stone risk in dogs.

AB - Background: There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis. Objective: To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis. Animals: Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria. Methods: Retrospective cross-sectional study. Serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH) 2 D], and 24,25-dihydroxyvitamin D [24,25(OH) 2 D] were measured. The ratios of 25(OH)D/24,25(OH) 2 D and 1,25(OH) 2 D/25(OH)D were compared between cases and controls. Results: There were no significant differences between cases and controls when comparing 25(OH)D, 24,25(OH) 2 D, 1,25(OH) 2 D, or 1,25(OH) 2 D/25(OH)D. Cases had higher 25(OH)D/24,25(OH) 2 D (median = 1.40, range = 0.98-1.58) compared to controls (median = 1.16, range = 0.92-2.75; P =.01). There was overlap in the ranges for 25(OH)D/24,25(OH) 2 D between cases and controls, but 6 cases (32%) had ratios above the control dog range. There was a moderate positive correlation between the ratio of 25(OH)D/24,25(OH) 2 D and urinary calcium-to-creatinine ratios (r = 0.40, 95% confidence interval = 0.10-0.64; P =.01). Conclusions and Clinical Importance: These data suggest that decreased conversion of 25(OH)D to 24,25(OH) 2 D occurs in a subset of dogs with CaOx urolithiasis. Abnormalities in vitamin D metabolism might contribute to stone risk in dogs.

KW - calcitriol

KW - canine

KW - hypercalciuria

KW - stones

UR - http://www.scopus.com/inward/record.url?scp=85062703166&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062703166&partnerID=8YFLogxK

U2 - 10.1111/jvim.15442

DO - 10.1111/jvim.15442

M3 - Article

C2 - 30851134

AN - SCOPUS:85062703166

VL - 33

SP - 758

EP - 763

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 2

ER -