Vitamin D Deficiency and Osteoporosis in Rehabilitation Inpatients

Leonid M. Shinchuk, Leslie Morse, Nadia Huancahuari, Seth Arum, Tai C. Chen, Michael F. Holick

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Shinchuk LM, Morse L, Huancahuari N, Arum S, Chen TC, Holick MF. Vitamin D deficiency and osteoporosis in rehabilitation inpatients. Objective: To determine vitamin D status and bone mineral density (BMD) in patients admitted to a subacute rehabilitation facility. Design: Cross-sectional cohort study. Setting: Subacute rehabilitation facility. Participants: Fifty-three community-dwelling patients admitted from June through February 2005. Interventions: Not applicable. Main Outcome Measures: BMD, 25-hydroxyvitamin D (25[OH]D), C-telopeptide (CTX), osteocalcin, and dietary milk intake. Results: Prevalence of vitamin D deficiency (25[OH]D <20ng/mL) was 49.1%, while a total of 83% of patients were either vitamin D deficient or insufficient (25[OH]D <30ng/mL). The prevalence of osteopenia (T score, <-1) was 52.8%; osteoporosis (T score, <-2.5) was 17.0%. CTX (bone resorption marker) was elevated in 60.4% of patients. Osteocalcin (bone formation marker) was elevated in 13.2% of patients. Measurements of bone resorption and formation positively correlated (R 2 =.22) indicating increased bone remodeling. Conclusions: Vitamin D deficiency and osteopenia and osteoporosis were highly prevalent in patients admitted for rehabilitation. Elevated bone resorption and remodeling were evident. This could be due to vitamin D deficiency that should be corrected before antiresorptive therapy is considered. The study emphasizes the need for vigilance for vitamin D status and BMD testing in patients admitted to rehabilitation facilities.

Original languageEnglish (US)
Pages (from-to)904-908
Number of pages5
JournalArchives of Physical Medicine and Rehabilitation
Issue number7
StatePublished - Jul 1 2006
Externally publishedYes


  • Bone density
  • Osteoporosis
  • Rehabilitation
  • Vitamin D deficiency


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