Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Rebecca M. Smith, Adam J. Black, Saalini S. Velamakanni, Taner Akkin, Elena G. Tolkacheva

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n = 5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)2713-2721
Number of pages9
JournalApplied Optics
Volume51
Issue number14
DOIs
StatePublished - May 10 2012

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rabbits
borders
arrhythmia
Tissue
Geometry
Optical tomography
geometry
myocardial infarction
clearing
Polarization
arteries
maintenance
tomography
spatial resolution
projection
high resolution
polarization

Cite this

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart. / Smith, Rebecca M.; Black, Adam J.; Velamakanni, Saalini S.; Akkin, Taner; Tolkacheva, Elena G.

In: Applied Optics, Vol. 51, No. 14, 10.05.2012, p. 2713-2721.

Research output: Contribution to journalArticle

Smith, Rebecca M. ; Black, Adam J. ; Velamakanni, Saalini S. ; Akkin, Taner ; Tolkacheva, Elena G. / Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart. In: Applied Optics. 2012 ; Vol. 51, No. 14. pp. 2713-2721.
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