Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Rebecca M. Smith; Adam J. Black; Saalini S. Velamakanni; Taner Akkin; Elena G. Tolkacheva

doi:10.1364/AO.51.002713

Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart

Rebecca M. Smith, Adam J. Black, Saalini S. Velamakanni, Taner Akkin, Elena G. Tolkacheva

Biomedical Engineering

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n = 5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.

Original language	English (US)
Pages (from-to)	2713-2721
Number of pages	9
Journal	Applied Optics
Volume	51
Issue number	14
DOIs	https://doi.org/10.1364/AO.51.002713
State	Published - May 10 2012

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Smith, R. M., Black, A. J., Velamakanni, S. S., Akkin, T., & Tolkacheva, E. G. (2012). Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart. Applied Optics, 51(14), 2713-2721. https://doi.org/10.1364/AO.51.002713

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10.1364/AO.51.002713