Abstract
Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n = 5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2713-2721 |
| Number of pages | 9 |
| Journal | Applied Optics |
| Volume | 51 |
| Issue number | 14 |
| DOIs | |
| State | Published - May 10 2012 |
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Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart. / Smith, Rebecca M.; Black, Adam J.; Velamakanni, Saalini S.; Akkin, Taner; Tolkacheva, Elena G.
In: Applied Optics, Vol. 51, No. 14, 10.05.2012, p. 2713-2721.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart
AU - Smith, Rebecca M.
AU - Black, Adam J.
AU - Velamakanni, Saalini S.
AU - Akkin, Taner
AU - Tolkacheva, Elena G.
PY - 2012/5/10
Y1 - 2012/5/10
N2 - Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n = 5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.
AB - Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n = 5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.
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UR - http://www.scopus.com/inward/citedby.url?scp=84861411043&partnerID=8YFLogxK
U2 - 10.1364/AO.51.002713
DO - 10.1364/AO.51.002713
M3 - Article
C2 - 22614494
AN - SCOPUS:84861411043
VL - 51
SP - 2713
EP - 2721
JO - Applied Optics
JF - Applied Optics
SN - 1559-128X
IS - 14
ER -