Visualization of specific B and T lymphocyte interactions in the lymph node

Paul Garside, Elizabeth Ingulli, Rebecca R Merica, Julia G. Johnson, Randolph J. Noelle, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

591 Scopus citations

Abstract

Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.

Original languageEnglish (US)
Pages (from-to)96-99
Number of pages4
JournalScience
Volume281
Issue number5373
DOIs
StatePublished - Jul 3 1998

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