Visual anomalies associated with albinism

Donnell J. Creel, C. Gail Summers, Richard A. King

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


All mammals with hypopigmentation of the retinal pigment epithelium have abnormal visual systems. Albino mammals have been found to have: (1) reduced numbers of uncrossed optic fibers projecting to all visual centers, (2) disorganization of the pattern (lamination) of the dorsal lateral geniculate nuclei, and (3) disorganization of projections from the dorsal lateral genic ulate nuclei to the visual cortex. The disorganization of central visual centers has catastrophic effects on stereovision and optokinetic nystagmus. Variable expression in oculocutaneous albinism suggests that affected individuals cannot always be identified by hypopigmentation, reduced visual acuity and nystagmus. Careful observation of foveal development in individuals even with normal vision is necessary to detect all persons with albinism. The scalp-recorded visually evoked potential designed to detect optic misrouting is the most reliable concomitant for determining albinism.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalOphthalmic Genetics
Issue number3
StatePublished - 1990


  • Albinism
  • Evoked potentials
  • Melanin
  • Vision


Dive into the research topics of 'Visual anomalies associated with albinism'. Together they form a unique fingerprint.

Cite this