Visual acuity, contrast sensitivity and color vision three years after iodine-125 brachytherapy for choroidal and ciliary body melanoma

Irena Tsui, Robert M. Beardsley, Tara A. McCannel, Scott C. Oliver, Melissa W. Chun, Steve P. Lee, Phillip E. Chow, Nzhde Agazaryan, Fei Yu, Bradley R. Straatsma

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: To report visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after iodine-125 brachytherapy for choroidal and ciliary body melanoma (CCM). Design: Prospective interventional case series. Participants: Thirty-seven patients (37 eyes) with CCM. Methods: Patients had best-corrected Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity, Pelli-Robson contrast sensitivity and Hardy-Rand-Rittler color vision measurement; comprehensive ophthalmology examination; optical coherence tomography; and ultrasonography at baseline prior to, 1 year after, 2 years after and 3 years after I-125 brachytherapy. Main Outcome Measures: Visual acuity, contrast sensitivity and color vision prior to, 1 year after, 2 years after and 3 years after brachytherapy. Results: Nineteen (19) men and 18 women with mean age of 58 years (SD 13, range 30-78) prior to, 1 year after, 2 years after and 3 years after brachytherapy had mean best-corrected visual acuity of 77 letters (20/32), 65 letters (20/50), 56 letters (20/80) and 47 letters (20/125); contrast sensitivity of 30, 26, 22 and 19 letters; color vision of 26, 20, 17 and 14 test figures, respectively. Decrease in visual acuity, contrast sensitivity and color vision was statistically significant from baseline at 1 year, 2 years, and 3 years after brachytherapy. Decreased acuity at 3 years was associated with mid-choroid and macula melanoma location, ≥ 4.1 mm melanoma height, radiation maculopathy and radiation optic neuropathy. Conclusion: 1, 2 and 3 years after brachytherapy, eyes with CCM had significantly decreased visual acuity, contrast sensitivity and color vision.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalOpen Ophthalmology Journal
Volume9
DOIs
StatePublished - 2015

Keywords

  • Brachytherapy
  • Choroidal melanoma
  • Ciliary body melanoma
  • Contrast sensitivity
  • Visual acuity

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