Viscosity matching positively affects the correlation of pressure-volume loops between in-vivo and ex-vivo models

Emma Schinstock, D'Anne Kudlik, Michael D Eggen, Paul A. Iaizzo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using Visible Heart® methodologies, swine hearts were reanimated and implanted with a left ventricular assist device (LVAD). System components were modified to better understand the relationships between the data collected and system conditions. The viscosity of the blood-replacement buffer was increased to a more physiologic value (~3 cP). Pressure-Volume (PV) loop recordings from each heart on the ex-vivo perfusion system more closely mimic loops recorded from the heart in-vivo. This indicates that any system aiming to characterize or examine LVAD performance must include a buffer which mimics blood viscosity or data must be adjusted for the relative viscosity of the buffer.

Original languageEnglish (US)
Title of host publicationProceedings of the 2021 Design of Medical Devices Conference, DMD 2021
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791884812
DOIs
StatePublished - May 11 2020
Event2021 Design of Medical Devices Conference, DMD 2021 - Virtual, Online
Duration: Apr 12 2021Apr 15 2021

Publication series

NameProceedings of the 2021 Design of Medical Devices Conference, DMD 2021

Conference

Conference2021 Design of Medical Devices Conference, DMD 2021
CityVirtual, Online
Period4/12/214/15/21

Bibliographical note

Publisher Copyright:
© 2021 by ASME.

Keywords

  • Ex-vivo heart perfusion
  • LVAD
  • PV loops

Fingerprint

Dive into the research topics of 'Viscosity matching positively affects the correlation of pressure-volume loops between in-vivo and ex-vivo models'. Together they form a unique fingerprint.

Cite this