Visceral adipose tissue measured by DXA correlates with measurement by CT and is associated with cardiometabolic risk factors in children

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Abstract

Background Visceral adipose tissue (VAT) generally demonstrates a stronger relationship with cardiometabolic risk factors than total body fat or subcutaneous adipose tissue. Objectives The purpose of this study was to compare VAT estimated in children by total volume dual-energy X-ray absorptiometry (DXA) with a gold standard measurement, single slice (L4-L5) computed tomography (CT). Methods A total of 329 (152 females, 177 males) children ages 6-18 years (mean age 12.3 ± 3.6) and with average body mass index percentile of 54.9% (3-99%) had their VAT estimated by both CT and DXA. Linear association between methods was measured using Pearson's correlation. Multiple linear regressions compared the associations between cardiometabolic risk factors and both CT-VAT and DXA-VAT, respectively. Results In children, DXA-VAT was correlated significantly with CT-VAT, with a stronger relationship in overweight and obese children. Multiple regression analysis showed that both estimates of VAT were significantly associated with lipids and insulin sensitivity, measured by euglycaemic-hyperinsulinaemic clamp. Additionally, DXA-VAT was associated with diastolic blood pressure, homeostasis model of insulin resistance and fasting insulin, but CT-VAT was not. Conclusion In children, total volume DXA-VAT and single slice CT-VAT are significantly correlated and each demonstrates similar associations with cardiometabolic risk factors. This suggests that DXA is a useful and valid method for estimation of VAT in children.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalPediatric Obesity
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2015

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Intra-Abdominal Fat
Photon Absorptiometry
Tomography
Insulin Resistance
Blood Pressure
Glucose Clamp Technique
Subcutaneous Fat
Adipose Tissue
Linear Models
Fasting
Body Mass Index
Homeostasis

Keywords

  • Body composition
  • insulin resistance
  • obesity
  • pediatrics

Cite this

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title = "Visceral adipose tissue measured by DXA correlates with measurement by CT and is associated with cardiometabolic risk factors in children",
abstract = "Background Visceral adipose tissue (VAT) generally demonstrates a stronger relationship with cardiometabolic risk factors than total body fat or subcutaneous adipose tissue. Objectives The purpose of this study was to compare VAT estimated in children by total volume dual-energy X-ray absorptiometry (DXA) with a gold standard measurement, single slice (L4-L5) computed tomography (CT). Methods A total of 329 (152 females, 177 males) children ages 6-18 years (mean age 12.3 ± 3.6) and with average body mass index percentile of 54.9{\%} (3-99{\%}) had their VAT estimated by both CT and DXA. Linear association between methods was measured using Pearson's correlation. Multiple linear regressions compared the associations between cardiometabolic risk factors and both CT-VAT and DXA-VAT, respectively. Results In children, DXA-VAT was correlated significantly with CT-VAT, with a stronger relationship in overweight and obese children. Multiple regression analysis showed that both estimates of VAT were significantly associated with lipids and insulin sensitivity, measured by euglycaemic-hyperinsulinaemic clamp. Additionally, DXA-VAT was associated with diastolic blood pressure, homeostasis model of insulin resistance and fasting insulin, but CT-VAT was not. Conclusion In children, total volume DXA-VAT and single slice CT-VAT are significantly correlated and each demonstrates similar associations with cardiometabolic risk factors. This suggests that DXA is a useful and valid method for estimation of VAT in children.",
keywords = "Body composition, insulin resistance, obesity, pediatrics",
author = "Bosch, {Tyler A} and Dengel, {Donald R} and Kelly, {Aaron S} and Sinaiko, {Alan R} and Antoinette Moran and Julia Steinberger",
year = "2015",
month = "6",
day = "1",
doi = "10.1111/ijpo.249",
language = "English (US)",
volume = "10",
pages = "172--179",
journal = "Pediatric obesity",
issn = "2047-6310",
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number = "3",

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T1 - Visceral adipose tissue measured by DXA correlates with measurement by CT and is associated with cardiometabolic risk factors in children

AU - Bosch, Tyler A

AU - Dengel, Donald R

AU - Kelly, Aaron S

AU - Sinaiko, Alan R

AU - Moran, Antoinette

AU - Steinberger, Julia

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Background Visceral adipose tissue (VAT) generally demonstrates a stronger relationship with cardiometabolic risk factors than total body fat or subcutaneous adipose tissue. Objectives The purpose of this study was to compare VAT estimated in children by total volume dual-energy X-ray absorptiometry (DXA) with a gold standard measurement, single slice (L4-L5) computed tomography (CT). Methods A total of 329 (152 females, 177 males) children ages 6-18 years (mean age 12.3 ± 3.6) and with average body mass index percentile of 54.9% (3-99%) had their VAT estimated by both CT and DXA. Linear association between methods was measured using Pearson's correlation. Multiple linear regressions compared the associations between cardiometabolic risk factors and both CT-VAT and DXA-VAT, respectively. Results In children, DXA-VAT was correlated significantly with CT-VAT, with a stronger relationship in overweight and obese children. Multiple regression analysis showed that both estimates of VAT were significantly associated with lipids and insulin sensitivity, measured by euglycaemic-hyperinsulinaemic clamp. Additionally, DXA-VAT was associated with diastolic blood pressure, homeostasis model of insulin resistance and fasting insulin, but CT-VAT was not. Conclusion In children, total volume DXA-VAT and single slice CT-VAT are significantly correlated and each demonstrates similar associations with cardiometabolic risk factors. This suggests that DXA is a useful and valid method for estimation of VAT in children.

AB - Background Visceral adipose tissue (VAT) generally demonstrates a stronger relationship with cardiometabolic risk factors than total body fat or subcutaneous adipose tissue. Objectives The purpose of this study was to compare VAT estimated in children by total volume dual-energy X-ray absorptiometry (DXA) with a gold standard measurement, single slice (L4-L5) computed tomography (CT). Methods A total of 329 (152 females, 177 males) children ages 6-18 years (mean age 12.3 ± 3.6) and with average body mass index percentile of 54.9% (3-99%) had their VAT estimated by both CT and DXA. Linear association between methods was measured using Pearson's correlation. Multiple linear regressions compared the associations between cardiometabolic risk factors and both CT-VAT and DXA-VAT, respectively. Results In children, DXA-VAT was correlated significantly with CT-VAT, with a stronger relationship in overweight and obese children. Multiple regression analysis showed that both estimates of VAT were significantly associated with lipids and insulin sensitivity, measured by euglycaemic-hyperinsulinaemic clamp. Additionally, DXA-VAT was associated with diastolic blood pressure, homeostasis model of insulin resistance and fasting insulin, but CT-VAT was not. Conclusion In children, total volume DXA-VAT and single slice CT-VAT are significantly correlated and each demonstrates similar associations with cardiometabolic risk factors. This suggests that DXA is a useful and valid method for estimation of VAT in children.

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