Virus mutators and antimutatorsroles in evolution, pathogenesis and emergence

Louis M. Mansky; Kristopher S. Cunningham

doi:10.1016/S0168-9525(00)02125-9

Virus mutators and antimutatorsroles in evolution, pathogenesis and emergence

Louis M. Mansky, Kristopher S. Cunningham

Diagnostic and Biological Sciences

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Virus mutators (mutant alleles that confer a higher mutant-frequency phenotype than that of the wild type) and antimutators (mutant alleles that confer a lower mutant-frequency phenotype) were discovered in bacteriophage T4 over three decades ago, but there is only limited detailed knowledge about such genetic variants in viruses that infect humans and threaten public health. The creation of mutators and antimutators during the course of viral infection (particularly in the case of RNA viruses) could play a pivotal role in virus evolution, pathogenesis and emergence, and could also frustrate antiviral therapy. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	512-517
Number of pages	6
Journal	Trends in Genetics
Volume	16
Issue number	11
DOIs	https://doi.org/10.1016/S0168-9525(00)02125-9
State	Published - Nov 1 2000

Bibliographical note

Funding Information:
Because of reference limitations, we regret not being able to cite all of our colleagues who have contributed to the literature discussed in this review. L.M.M. is supported by the Public Health Service (GM56615), the American Cancer Society (RPG0027801), and the Ohio Cancer Research Associates.

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abstract = "Virus mutators (mutant alleles that confer a higher mutant-frequency phenotype than that of the wild type) and antimutators (mutant alleles that confer a lower mutant-frequency phenotype) were discovered in bacteriophage T4 over three decades ago, but there is only limited detailed knowledge about such genetic variants in viruses that infect humans and threaten public health. The creation of mutators and antimutators during the course of viral infection (particularly in the case of RNA viruses) could play a pivotal role in virus evolution, pathogenesis and emergence, and could also frustrate antiviral therapy. Copyright (C) 2000 Elsevier Science Ltd.",

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Virus mutators and antimutatorsroles in evolution, pathogenesis and emergence

Abstract

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