Virus and immune responses: Lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis

M. B.A. Oldstone, R. Ahmed, J. Byrne, M. J. Buchmeier, Y. Riviere, P. Southern

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Several of the major advances in contemporary virology and immunology came about through the study of lymphocytic choriomeningitis virus and the infection it produces. Included are concepts in immunologic tolerance, virus-antibody immune complexes, cytotoxic T cell generation, H-2 restriction, virally-induced immunopathology and the cessation of infected cells differentiated function without their destruction as a cause of disease. These concepts are reviewed and brought up to date in this report.

Original languageEnglish (US)
Pages (from-to)70-74
Number of pages5
JournalBritish Medical Bulletin
Volume41
Issue number1
DOIs
StatePublished - 1985

Bibliographical note

Funding Information:
ACKNOWLEDGEMENTS This research was supported by US Public Health Service grants AI-09484, NS-12428, AG-04342 and AI-16102. M.J.B is an Established Investigator of the American Heart Association, J.B. received post-

Funding Information:
doctoral fellowship support from USPHS training grant No. NS-07078 and Y R. from the Pasteur Institute and the Fondation de l'lndustrie Pharmaceutique pour la Recherche.

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