Virulence regulation in Staphylococcus aureus: The need for in vivo analysis of virulence factor regulation

Alexa A Pragman, Patrick M. Schlievert

Research output: Contribution to journalShort surveypeer-review

62 Scopus citations

Abstract

Staphylococcus aureus is a pathogenic microorganism that is responsible for a wide variety of clinical infections. These infections can be relatively mild, but serious, life-threatening infections may result from the expression of staphylococcal virulence factors that are coordinated by virulence regulators. Much work has been done to characterize the actions of staphylococcal virulence regulators in broth culture. Recently, several laboratories showed that transcriptional analyses of virulence regulators in in vivo animal models or in human infection did not correlate with transcriptional analyses accomplished in vitro. In describing the differences between in vitro and in vivo transcription of staphylococcal virulence regulators, we hope to encourage investigators to study virulence regulators using infection models whenever possible.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalFEMS Immunology and Medical Microbiology
Volume42
Issue number2
DOIs
StatePublished - Oct 1 2004

Keywords

  • SrrAB
  • Staphylococcus aureus
  • Two-component systems
  • Virulence regular

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