Virulence of pneumococcal proteins on the inner ear

Patricia A. Schachern, Vladimir Tsuprun, Sebahattin Cureoglu, Patricia Ferrieri, David E. Briles, Michael M. Paparella, Steven Juhn

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear. Main Outcome Measures: A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear. Results: Most of the animals inoculated with highdose pneumolysin or wild-type bacteria showed severe pathologic changes of the inner ears. The inner ears of most animals inoculated with surface protein A or surface antigen A-deficient bacteria appeared normal. Conclusions: Pneumococcal surface protein A and pneumococcal surface antigen A are 2 important virulence factors in inner ear damage secondary to pneumococcal otitis media. Mutation of these virulence factors results in less inner ear damage.

Original languageEnglish (US)
Pages (from-to)657-661
Number of pages5
JournalArchives of Otolaryngology - Head and Neck Surgery
Issue number7
StatePublished - Jul 2009


Dive into the research topics of 'Virulence of pneumococcal proteins on the inner ear'. Together they form a unique fingerprint.

Cite this