Virtual prototyping: Computational device placements within detailed human heart models

Alex J. Deakyne, Tinen L. Iles, Alexander R. Mattson, Paul A. Iaizzo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Data relative to anatomical measurements, spatial relationships, and device-tissue interaction are invaluable to medical device designers. However, obtaining these datasets from a wide range of anatomical specimens can be difficult and time consuming, forcing designers to make decisions on the requisite shapes and sizes of a device from a restricted number of specimens. The Visible Heart® Laboratories have a unique library of over 500 perfusion-fixed human cardiac specimens from organ donors whose hearts (and or lungs) were not deemed viable for transplantation. These hearts encompass a wide variety of pathologies, patient demographics, surgical repairs, and/or interventional procedures. Further, these specimens are an important resource for anatomical study, and their utility may be augmented via generation of 3D computational anatomical models, i.e., from obtained post-fixation magnetic resonance imaging (MRI) scans. In order to optimize device designs and procedural developments, computer generated models of medical devices and delivery tools can be computationally positioned within any of the generated anatomical models. The resulting co-registered 3D models can be 3D printed and analyzed to better understand relative interfaces between a specific device and cardiac tissues within a large number of diverse cardiac specimens that would be otherwise unattainable.

Original languageEnglish (US)
Article number175
JournalApplied Sciences (Switzerland)
Issue number1
StatePublished - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2019 by the authors.


  • 3D printing
  • Cardiac anatomy
  • Computational modeling
  • Medical devices
  • Medical imaging


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