Viral vectors for gene therapy

Paul D. Robbins, Hideaki Tahara, Steven C. Ghivizzani

Research output: Contribution to journalReview articlepeer-review

205 Scopus citations


Gene therapy is now being applied to the treatment of a wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses, herpes- simplex viruses and adeno-associated viruses. These vital vectors have a number of specific advantages and disadvantages that make them suited to particular gene-therapeutic applications. This review will summarize the current status of the development of viral vectors for gene therapy.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalTrends in biotechnology
Issue number1
StatePublished - Jan 1998
Externally publishedYes


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