Abstract
We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during the first 24 weeks after diagnosis in untreated participants and those who started antiretroviral therapy (ART) immediately at diagnosis. In the absence of treatment, semen viral load was >1000 copies/mL in almost all specimens (83%) collected 2–10 weeks after the estimated date of HIV acquisition and remained >1000 copies/mL in 35% of untreated participants at the last observed time point. Thus, in the absence of ART, semen viral load remained at a level consistent with transmissibility throughout primary infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1141-1146 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 229 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 15 2024 |
Bibliographical note
Publisher Copyright:© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved.
Keywords
- HIV
- antiretroviral therapy (ART)
- blood
- plasma
- semen
- seminal plasma
- viral load
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
