Viral Infections of the Fetus and Newborn

Mark R Schleiss, Ketzela J. Marsh

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Viral infections of the fetus and newborn are common problems in neonatology practice and must be considered in the differential diagnosis of newborns with intrauterine growth retardation, physical examination and laboratory abnormalities, and illness in the newborn period. The diversity of fetal and neonatal viral infections is vast. The depth and breadth of viral disease are extensive and the differential diagnosis broad. Clinicians should consider specific causes and not rely on broad-based categorical consideration of Toxoplasmosis, Other, Rubella, Cytomegalovirus, Herpes Simplex Virus (TORCH) syndromes, since specific signs, symptoms, and findings are quite diverse, depending on the pathogen being considered. Antiviral therapies are now available for many of these pathogens, underscoring the importance of making a specific diagnosis. Laboratory studies focused on virologic detection, driven in most cases by molecular assays, are much more precise and reliable than serologic diagnosis.

Original languageEnglish (US)
Title of host publicationAvery's Diseases of the Newborn
Subtitle of host publicationTenth Edition
PublisherElsevier Inc.
ISBN (Electronic)9780323401722
ISBN (Print)9780323401395
StatePublished - 2018


  • Antiviral therapy
  • Congenital infection
  • Perinatal infection
  • Placenta
  • TORCH infection
  • Viral teratogen
  • Viral vaccine


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