Viral Diseases Explorer: a webtool to identify viral disease information derived from multiple LLMs

Oscar Rojas Labra; Carla M. Martinez-Garcia; Nelly Santoyo-Rivera; Daniel Montiel-Garcia; Vijay S. Reddy

doi:10.1093/bioinformatics/btaf613

Viral Diseases Explorer: a webtool to identify viral disease information derived from multiple LLMs

Oscar Rojas Labra
, Carla M. Martinez-Garcia
, Nelly Santoyo-Rivera
, Daniel Montiel-Garcia
, Vijay S. Reddy

The Hormel Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Motivation: With nearly 266,500 viruses cataloged currently at NCBI and increasing by the day, identifying the diseases they cause, and the affected hosts remains challenging. Hence the motivation for undertaking this study. Results: Utilizing the AI-powered tools, we obtained disease information for 165 363 viruses, identifying 2833 unique diseases affecting 5503 distinct hosts and designated consensus diseases confirmed by three LLMs. Using this information, we developed the Viral Diseases Explorer webtool that enables the searches of diseases linked to specific viruses, viruses causing particular diseases, and viruses infecting specific hosts. Availability and implementation: Viral Diseases Explorer tool can be accessed from the URL: https://virus-world.org/viral_diseases_explorer.php

Original language	English (US)
Article number	btaf613
Journal	Bioinformatics
Volume	41
Issue number	11
DOIs	https://doi.org/10.1093/bioinformatics/btaf613
State	Published - Nov 1 2025

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© The Author(s) 2025. Published by Oxford University Press.

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10.1093/bioinformatics/btaf613

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title = "Viral Diseases Explorer: a webtool to identify viral disease information derived from multiple LLMs",

abstract = "Motivation: With nearly 266,500 viruses cataloged currently at NCBI and increasing by the day, identifying the diseases they cause, and the affected hosts remains challenging. Hence the motivation for undertaking this study. Results: Utilizing the AI-powered tools, we obtained disease information for 165 363 viruses, identifying 2833 unique diseases affecting 5503 distinct hosts and designated consensus diseases confirmed by three LLMs. Using this information, we developed the Viral Diseases Explorer webtool that enables the searches of diseases linked to specific viruses, viruses causing particular diseases, and viruses infecting specific hosts. Availability and implementation: Viral Diseases Explorer tool can be accessed from the URL: https://virus-world.org/viral\_diseases\_explorer.php",

author = "\{Rojas Labra\}, Oscar and Martinez-Garcia, \{Carla M.\} and Nelly Santoyo-Rivera and Daniel Montiel-Garcia and Reddy, \{Vijay S.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025. Published by Oxford University Press.",

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AU - Montiel-Garcia, Daniel

AU - Reddy, Vijay S.

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Viral Diseases Explorer: a webtool to identify viral disease information derived from multiple LLMs

Abstract

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