VIPERdb v3.0: A structure-based data analytics platform for viral capsids

Daniel Montiel-Garcia, Nelly Santoyo-Rivera, Phuong Ho, Mauricio Carrillo-Tripp, Charles L. Brooks, John E. Johnson, Vijay S. Reddy

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


VIrus Particle ExploreR data base (VIPERdb) ( is a curated repository of virus capsid structures and a database of structure-derived data along with various virus specific information. VIPERdb has been continuously improved for over 20 years and contains a number of virus structure analysis tools. The release of VIPERdb v3.0 contains new structure-based data analytics tools like Multiple Structure-based and Sequence Alignment (MSSA) to identify hot-spot residues within a selected group of structures and an anomaly detection application to analyze and curate the structure-derived data within individual virus families. At the time of this writing, there are 931 virus structures from 62 different virus families in the database. Significantly, the new release also contains a standalone database called 'Virus World database' (VWdb) that comprises all the characterized viruses (∼181 000) known to date, gathered from ICTVdb and NCBI, and their capsid protein sequences, organized according to their virus taxonomy with links to known structures in VIPERdb and PDB. Moreover, the new release of VIPERdb includes a service-oriented data engine to handle all the data access requests and provides an interface for futuristic data analytics using machine leaning applications.

Original languageEnglish (US)
Pages (from-to)D809-D816
JournalNucleic acids research
Issue numberD1
StatePublished - Jan 8 2021
Externally publishedYes

Bibliographical note

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact


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