Vinorelbine rescue therapy for dogs with primary urinary bladder carcinoma

M. E. Kaye, D. H. Thamm, K. Weishaar, J. A. Lawrence

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The goal of this study was to evaluate the anti-tumour activity and toxicoses of vinorelbine as a palliative rescue therapy for dogs with primary urinary bladder carcinoma. Thirteen dogs refractory to prior chemotherapeutics and one dog naïve to chemotherapeutic treatment were enrolled. Vinorelbine (15 mgm-2 IV) was administered intravenously along with concurrent oral anti-inflammatory drugs, if tolerated. A median of six doses of vinorelbine (range: 1-16) was administered. Two dogs (14%) had partial responses, and eight (57%) experienced stable disease. Subjective improvement in clinical signs was noted in 11 dogs (78%). Adverse events were mild and primarily haematological in nature. Median time to progression was 93 days (range: 20-239 days). Median survival time for all dogs was 187 days; median survival for 13 pre-treated dogs was 207 days. Vinorelbine may have utility in the management of canine primary urinary bladder carcinoma and should be evaluated in a prospective study.

Original languageEnglish (US)
Pages (from-to)443-451
Number of pages9
JournalVeterinary and Comparative Oncology
Volume13
Issue number4
DOIs
StatePublished - Dec 2015

Keywords

  • Canine
  • Oncology
  • Quality of life
  • Urogenital medicine

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