Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

Judd F. Hultquist, Mawuena Binka, Rebecca S LaRue, Viviana Simon, Reuben Harris

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBFβ allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins from multiple HIV-1 subtypes and is required for the degradation of all human and rhesus Vif-sensitive APOBEC3 proteins by their respective lentiviral Vif proteins.

Original languageEnglish (US)
Pages (from-to)2874-2877
Number of pages4
JournalJournal of virology
Volume86
Issue number5
DOIs
StatePublished - Mar 2012

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