Vertebroplasty for vertebral compression fractures

Placebo or effective?

Arvin Wali, Joel Martin, Robert Rennert, Daniel Resnick, William Taylor, Peter Warnke, Clark Chen

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared the use of VP vs. a sham surgery control group. Notably, RCTs comparing nonsurgically treated patients as a control group vs. those undergoing VP uniformly reported that VP contributed to improved pain relief. In contrast, RCTs comparing sham surgery vs. VP uniformly reported no significant differences between the two groups.

Original languageEnglish (US)
JournalSurgical Neurology International
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Vertebroplasty
Compression Fractures
Placebos
Control Groups
Pain
Placebo Effect

Keywords

  • Placebo effect
  • Randomized-controlled trials
  • Sham-controlled surgery
  • Vertebral compression fractures
  • Vertebroplasty

Cite this

Vertebroplasty for vertebral compression fractures : Placebo or effective? / Wali, Arvin; Martin, Joel; Rennert, Robert; Resnick, Daniel; Taylor, William; Warnke, Peter; Chen, Clark.

In: Surgical Neurology International, Vol. 8, No. 1, 01.01.2017.

Research output: Contribution to journalReview article

Wali, Arvin ; Martin, Joel ; Rennert, Robert ; Resnick, Daniel ; Taylor, William ; Warnke, Peter ; Chen, Clark. / Vertebroplasty for vertebral compression fractures : Placebo or effective?. In: Surgical Neurology International. 2017 ; Vol. 8, No. 1.
@article{31775e70f4b34b9cba75d708ed7f515a,
title = "Vertebroplasty for vertebral compression fractures: Placebo or effective?",
abstract = "Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared the use of VP vs. a sham surgery control group. Notably, RCTs comparing nonsurgically treated patients as a control group vs. those undergoing VP uniformly reported that VP contributed to improved pain relief. In contrast, RCTs comparing sham surgery vs. VP uniformly reported no significant differences between the two groups.",
keywords = "Placebo effect, Randomized-controlled trials, Sham-controlled surgery, Vertebral compression fractures, Vertebroplasty",
author = "Arvin Wali and Joel Martin and Robert Rennert and Daniel Resnick and William Taylor and Peter Warnke and Clark Chen",
year = "2017",
month = "1",
day = "1",
doi = "10.4103/sni.sni_2_17",
language = "English (US)",
volume = "8",
journal = "Surgical Neurology International",
issn = "2152-7806",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

TY - JOUR

T1 - Vertebroplasty for vertebral compression fractures

T2 - Placebo or effective?

AU - Wali, Arvin

AU - Martin, Joel

AU - Rennert, Robert

AU - Resnick, Daniel

AU - Taylor, William

AU - Warnke, Peter

AU - Chen, Clark

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared the use of VP vs. a sham surgery control group. Notably, RCTs comparing nonsurgically treated patients as a control group vs. those undergoing VP uniformly reported that VP contributed to improved pain relief. In contrast, RCTs comparing sham surgery vs. VP uniformly reported no significant differences between the two groups.

AB - Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared the use of VP vs. a sham surgery control group. Notably, RCTs comparing nonsurgically treated patients as a control group vs. those undergoing VP uniformly reported that VP contributed to improved pain relief. In contrast, RCTs comparing sham surgery vs. VP uniformly reported no significant differences between the two groups.

KW - Placebo effect

KW - Randomized-controlled trials

KW - Sham-controlled surgery

KW - Vertebral compression fractures

KW - Vertebroplasty

UR - http://www.scopus.com/inward/record.url?scp=85020432510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020432510&partnerID=8YFLogxK

U2 - 10.4103/sni.sni_2_17

DO - 10.4103/sni.sni_2_17

M3 - Review article

VL - 8

JO - Surgical Neurology International

JF - Surgical Neurology International

SN - 2152-7806

IS - 1

ER -