Vertebrate maternal-effect genes: Insights into fertilization, early cleavage divisions, and germ cell determinant localization from studies in the Zebrafish

Robin E. Lindeman, Francisco Pelegri

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

In the earliest stages of animal development prior to the commencement of zygotic transcription, all critical cellular processes are carried out by maternally-provided molecular products accumulated in the egg during oogenesis. Disruption of these maternal products can lead to defective embryogenesis. In this review, we focus on maternal genes with roles in the fundamental processes of fertilization, cell division, centrosome regulation, and germ cell development with emphasis on findings from the zebrafish, as this is a unique and valuable model system for vertebrate reproduction.

Original languageEnglish (US)
Pages (from-to)299-313
Number of pages15
JournalMolecular Reproduction and Development
Volume77
Issue number4
DOIs
StatePublished - Apr 2010

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