Venturing into the New Science of Nucleases

Markéta Tolarová; John A. McGrath; Jakub Tolar

doi:10.1016/j.jid.2016.01.021

Venturing into the New Science of Nucleases

Markéta Tolarová, John A. McGrath, Jakub Tolar

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.

Original language	English (US)
Pages (from-to)	742-745
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	136
Issue number	4
DOIs	https://doi.org/10.1016/j.jid.2016.01.021
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 The Authors

Publisher link

10.1016/j.jid.2016.01.021

Find It

Find It at U of M Libraries

Cite this

@article{ca7ff68d327e4eea9f7938ffb5fbf94a,

title = "Venturing into the New Science of Nucleases",

abstract = "Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.",

author = "Mark{\'e}ta Tolarov{\'a} and McGrath, {John A.} and Jakub Tolar",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors",

year = "2016",

doi = "10.1016/j.jid.2016.01.021",

language = "English (US)",

volume = "136",

pages = "742--745",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Venturing into the New Science of Nucleases

AU - Tolarová, Markéta

AU - McGrath, John A.

AU - Tolar, Jakub

PY - 2016

Y1 - 2016

N2 - Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.

AB - Gene editing with zinc finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated proteins system, or meganucleases can, in principle, mediate any genome modification. Recent studies have shown that COL7A1 mutations in cells of patients with recessive dystrophic epidermolysis bullosa can be corrected by homology-directed DNA repair.

UR - http://www.scopus.com/inward/record.url?scp=84978039474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978039474&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2016.01.021

DO - 10.1016/j.jid.2016.01.021

M3 - Comment/debate

C2 - 27012560

AN - SCOPUS:84978039474

SN - 0022-202X

VL - 136

SP - 742

EP - 745

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 4

ER -