Ventromedial Prefrontal Cortex Tracks Multiple Environmental Variables during Search

Priyanka S. Mehta, Jiaxin Cindy Tu, Giuliana A. LoConte, Meghan C. Pesce, Ben Y Hayden

Research output: Contribution to journalArticle

Abstract

To make efficient foraging decisions, we must combine information about the values of available options with nonvalue information. Some accounts of ventromedial PFC (vmPFC) suggest that it has a narrow role limited to evaluating immediately available options. We examined responses of neurons in area 14 (a putative macaque homolog of human vmPFC) as 2 male macaques performed a novel foraging search task. Although many neurons encoded the values of immediately available offers, they also independently encoded several other variables that influence choice, but that are conceptually distinct from offer value. These variables include average reward rate, number of offers viewed per trial, previous offer values, previous outcome sizes, and the locations of the currently attended offer. We conclude that, rather than serving as specialized economic value center, vmPFC plays a broad role in integrating relevant environmental information to drive foraging decisions.SIGNIFICANCE STATEMENT Decision makers must often choose whether to take an immediately available option or continue to search for a better one. We hypothesized that this process, which is integral to foraging theory, leaves neural signatures in the brain region ventromedial PFC. Subjects performed a novel foraging task in which they searched through differently valued options and attempted to balance their reward threshold with various time costs. We found that neurons not only encode the values of immediately available offers, but multiplexed these with environmental variables, including reward rate, number of offers viewed, previous offer values, and spatial information. We conclude that vmPFC plays a rich role in encoding and integrating multiple foraging-related variables during economic decisions.

Original languageEnglish (US)
Pages (from-to)5336-5350
Number of pages15
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume39
Issue number27
DOIs
StatePublished - Jul 3 2019

Fingerprint

Prefrontal Cortex
Reward
Macaca
Neurons
Economics
Costs and Cost Analysis
Brain

Keywords

  • electrophysiology
  • foraging
  • neuroeconomics
  • search
  • value
  • vmPFC

PubMed: MeSH publication types

  • Journal Article

Cite this

Ventromedial Prefrontal Cortex Tracks Multiple Environmental Variables during Search. / Mehta, Priyanka S.; Tu, Jiaxin Cindy; LoConte, Giuliana A.; Pesce, Meghan C.; Hayden, Ben Y.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 39, No. 27, 03.07.2019, p. 5336-5350.

Research output: Contribution to journalArticle

Mehta, Priyanka S. ; Tu, Jiaxin Cindy ; LoConte, Giuliana A. ; Pesce, Meghan C. ; Hayden, Ben Y. / Ventromedial Prefrontal Cortex Tracks Multiple Environmental Variables during Search. In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 ; Vol. 39, No. 27. pp. 5336-5350.
@article{4fe9068a45a347c4a22371cf14d012a4,
title = "Ventromedial Prefrontal Cortex Tracks Multiple Environmental Variables during Search",
abstract = "To make efficient foraging decisions, we must combine information about the values of available options with nonvalue information. Some accounts of ventromedial PFC (vmPFC) suggest that it has a narrow role limited to evaluating immediately available options. We examined responses of neurons in area 14 (a putative macaque homolog of human vmPFC) as 2 male macaques performed a novel foraging search task. Although many neurons encoded the values of immediately available offers, they also independently encoded several other variables that influence choice, but that are conceptually distinct from offer value. These variables include average reward rate, number of offers viewed per trial, previous offer values, previous outcome sizes, and the locations of the currently attended offer. We conclude that, rather than serving as specialized economic value center, vmPFC plays a broad role in integrating relevant environmental information to drive foraging decisions.SIGNIFICANCE STATEMENT Decision makers must often choose whether to take an immediately available option or continue to search for a better one. We hypothesized that this process, which is integral to foraging theory, leaves neural signatures in the brain region ventromedial PFC. Subjects performed a novel foraging task in which they searched through differently valued options and attempted to balance their reward threshold with various time costs. We found that neurons not only encode the values of immediately available offers, but multiplexed these with environmental variables, including reward rate, number of offers viewed, previous offer values, and spatial information. We conclude that vmPFC plays a rich role in encoding and integrating multiple foraging-related variables during economic decisions.",
keywords = "electrophysiology, foraging, neuroeconomics, search, value, vmPFC",
author = "Mehta, {Priyanka S.} and Tu, {Jiaxin Cindy} and LoConte, {Giuliana A.} and Pesce, {Meghan C.} and Hayden, {Ben Y}",
year = "2019",
month = "7",
day = "3",
doi = "10.1523/JNEUROSCI.2365-18.2019",
language = "English (US)",
volume = "39",
pages = "5336--5350",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "27",

}

TY - JOUR

T1 - Ventromedial Prefrontal Cortex Tracks Multiple Environmental Variables during Search

AU - Mehta, Priyanka S.

AU - Tu, Jiaxin Cindy

AU - LoConte, Giuliana A.

AU - Pesce, Meghan C.

AU - Hayden, Ben Y

PY - 2019/7/3

Y1 - 2019/7/3

N2 - To make efficient foraging decisions, we must combine information about the values of available options with nonvalue information. Some accounts of ventromedial PFC (vmPFC) suggest that it has a narrow role limited to evaluating immediately available options. We examined responses of neurons in area 14 (a putative macaque homolog of human vmPFC) as 2 male macaques performed a novel foraging search task. Although many neurons encoded the values of immediately available offers, they also independently encoded several other variables that influence choice, but that are conceptually distinct from offer value. These variables include average reward rate, number of offers viewed per trial, previous offer values, previous outcome sizes, and the locations of the currently attended offer. We conclude that, rather than serving as specialized economic value center, vmPFC plays a broad role in integrating relevant environmental information to drive foraging decisions.SIGNIFICANCE STATEMENT Decision makers must often choose whether to take an immediately available option or continue to search for a better one. We hypothesized that this process, which is integral to foraging theory, leaves neural signatures in the brain region ventromedial PFC. Subjects performed a novel foraging task in which they searched through differently valued options and attempted to balance their reward threshold with various time costs. We found that neurons not only encode the values of immediately available offers, but multiplexed these with environmental variables, including reward rate, number of offers viewed, previous offer values, and spatial information. We conclude that vmPFC plays a rich role in encoding and integrating multiple foraging-related variables during economic decisions.

AB - To make efficient foraging decisions, we must combine information about the values of available options with nonvalue information. Some accounts of ventromedial PFC (vmPFC) suggest that it has a narrow role limited to evaluating immediately available options. We examined responses of neurons in area 14 (a putative macaque homolog of human vmPFC) as 2 male macaques performed a novel foraging search task. Although many neurons encoded the values of immediately available offers, they also independently encoded several other variables that influence choice, but that are conceptually distinct from offer value. These variables include average reward rate, number of offers viewed per trial, previous offer values, previous outcome sizes, and the locations of the currently attended offer. We conclude that, rather than serving as specialized economic value center, vmPFC plays a broad role in integrating relevant environmental information to drive foraging decisions.SIGNIFICANCE STATEMENT Decision makers must often choose whether to take an immediately available option or continue to search for a better one. We hypothesized that this process, which is integral to foraging theory, leaves neural signatures in the brain region ventromedial PFC. Subjects performed a novel foraging task in which they searched through differently valued options and attempted to balance their reward threshold with various time costs. We found that neurons not only encode the values of immediately available offers, but multiplexed these with environmental variables, including reward rate, number of offers viewed, previous offer values, and spatial information. We conclude that vmPFC plays a rich role in encoding and integrating multiple foraging-related variables during economic decisions.

KW - electrophysiology

KW - foraging

KW - neuroeconomics

KW - search

KW - value

KW - vmPFC

UR - http://www.scopus.com/inward/record.url?scp=85069272293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069272293&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.2365-18.2019

DO - 10.1523/JNEUROSCI.2365-18.2019

M3 - Article

VL - 39

SP - 5336

EP - 5350

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 27

ER -