Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart

Toshihiro Tsuruda; Michihisa Jougasaki; Guido Boerrigter; Lisa C. Costello-Boerrigter; Alessandro Cataliotti; Shang C. Lee; Lisa Salz-Gilman; Lynda J. Nordstrom; Christopher G.A. McGregor; John C. Burnett

doi:10.1016/S0167-0115(03)00035-1

Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart

Toshihiro Tsuruda, Michihisa Jougasaki, Guido Boerrigter, Lisa C. Costello-Boerrigter, Alessandro Cataliotti, Shang C. Lee, Lisa Salz-Gilman, Lynda J. Nordstrom, Christopher G.A. McGregor, John C. Burnett

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Adrenomedullin (ADM) is a vasoactive and natriuretic peptide. While it is known that ADM is increased in failing human ventricles, the expression of ADM in human ventricular allografts remains unknown. The present study was designed to investigate tissue localization and intensity of ADM expression in ventricular biopsy specimens and to characterize ventricular ADM in human cardiac allografts. Thirty-three post-transplant endomyocardial biopsy specimens were examined immunohistochemically. The average score (range: 0-4) of ADM immunoreactivity (IR) was 2.4±0.9 (mean±standard deviation). Right ventricular (RV) systolic pressure was significantly increased with high ADM-IR (p=0.048) and the ADM-IR positively associated with myocyte size (r²=0.23, p=0.010). In contrast, ADM-IR was not associated with systemic blood pressure, serum creatinine, cyclosporine concentration, cardiac fibrosis, or allograft rejection. The present study shows that ADM-IR is present in human ventricular endomyocardium after transplantation, and ADM-IR is associated with the magnitude of RV pressure and myocyte size, suggesting an important role for ventricular ADM in the counteraction against overload as well as in the progress of myocyte hypertrophy after heart transplantation.

Original language	English (US)
Pages (from-to)	161-166
Number of pages	6
Journal	Regulatory Peptides
Volume	112
Issue number	1-3
DOIs	https://doi.org/10.1016/S0167-0115(03)00035-1
State	Published - Apr 15 2003
Externally published	Yes

Bibliographical note

Funding Information:
We thank Dr. Kenji Notohara, Division of Anatomic Pathology, Mayo Clinic Rochester, for helpful discussion. This work was supported by grants from the American Heart Association of the Minnesota Affiliate (MN-97-GB-06), the National Institutes of Health (HL36634 and HL07111), the Miami Heart Research Institute, the Bruce and Ruth Rappaport Program in Vascular Biology and the Mayo Foundation. The first author was supported by a fellowship of the Japan Heart Foundation. We gratefully thank Linda Combs for her assistance in preparing the manuscript.

Keywords

Adrenomedullin
Heart transplantation
Human
Hypertrophy
Rejection

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10.1016/S0167-0115(03)00035-1

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title = "Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart",

abstract = "Adrenomedullin (ADM) is a vasoactive and natriuretic peptide. While it is known that ADM is increased in failing human ventricles, the expression of ADM in human ventricular allografts remains unknown. The present study was designed to investigate tissue localization and intensity of ADM expression in ventricular biopsy specimens and to characterize ventricular ADM in human cardiac allografts. Thirty-three post-transplant endomyocardial biopsy specimens were examined immunohistochemically. The average score (range: 0-4) of ADM immunoreactivity (IR) was 2.4±0.9 (mean±standard deviation). Right ventricular (RV) systolic pressure was significantly increased with high ADM-IR (p=0.048) and the ADM-IR positively associated with myocyte size (r2=0.23, p=0.010). In contrast, ADM-IR was not associated with systemic blood pressure, serum creatinine, cyclosporine concentration, cardiac fibrosis, or allograft rejection. The present study shows that ADM-IR is present in human ventricular endomyocardium after transplantation, and ADM-IR is associated with the magnitude of RV pressure and myocyte size, suggesting an important role for ventricular ADM in the counteraction against overload as well as in the progress of myocyte hypertrophy after heart transplantation.",

keywords = "Adrenomedullin, Heart transplantation, Human, Hypertrophy, Rejection",

author = "Toshihiro Tsuruda and Michihisa Jougasaki and Guido Boerrigter and Costello-Boerrigter, {Lisa C.} and Alessandro Cataliotti and Lee, {Shang C.} and Lisa Salz-Gilman and Nordstrom, {Lynda J.} and McGregor, {Christopher G.A.} and Burnett, {John C.}",

note = "Funding Information: We thank Dr. Kenji Notohara, Division of Anatomic Pathology, Mayo Clinic Rochester, for helpful discussion. This work was supported by grants from the American Heart Association of the Minnesota Affiliate (MN-97-GB-06), the National Institutes of Health (HL36634 and HL07111), the Miami Heart Research Institute, the Bruce and Ruth Rappaport Program in Vascular Biology and the Mayo Foundation. The first author was supported by a fellowship of the Japan Heart Foundation. We gratefully thank Linda Combs for her assistance in preparing the manuscript.",

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doi = "10.1016/S0167-0115(03)00035-1",

language = "English (US)",

volume = "112",

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T1 - Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart

AU - Tsuruda, Toshihiro

AU - Jougasaki, Michihisa

AU - Boerrigter, Guido

AU - Costello-Boerrigter, Lisa C.

AU - Cataliotti, Alessandro

AU - Lee, Shang C.

AU - Salz-Gilman, Lisa

AU - Nordstrom, Lynda J.

AU - McGregor, Christopher G.A.

AU - Burnett, John C.

N1 - Funding Information: We thank Dr. Kenji Notohara, Division of Anatomic Pathology, Mayo Clinic Rochester, for helpful discussion. This work was supported by grants from the American Heart Association of the Minnesota Affiliate (MN-97-GB-06), the National Institutes of Health (HL36634 and HL07111), the Miami Heart Research Institute, the Bruce and Ruth Rappaport Program in Vascular Biology and the Mayo Foundation. The first author was supported by a fellowship of the Japan Heart Foundation. We gratefully thank Linda Combs for her assistance in preparing the manuscript.

PY - 2003/4/15

Y1 - 2003/4/15

N2 - Adrenomedullin (ADM) is a vasoactive and natriuretic peptide. While it is known that ADM is increased in failing human ventricles, the expression of ADM in human ventricular allografts remains unknown. The present study was designed to investigate tissue localization and intensity of ADM expression in ventricular biopsy specimens and to characterize ventricular ADM in human cardiac allografts. Thirty-three post-transplant endomyocardial biopsy specimens were examined immunohistochemically. The average score (range: 0-4) of ADM immunoreactivity (IR) was 2.4±0.9 (mean±standard deviation). Right ventricular (RV) systolic pressure was significantly increased with high ADM-IR (p=0.048) and the ADM-IR positively associated with myocyte size (r2=0.23, p=0.010). In contrast, ADM-IR was not associated with systemic blood pressure, serum creatinine, cyclosporine concentration, cardiac fibrosis, or allograft rejection. The present study shows that ADM-IR is present in human ventricular endomyocardium after transplantation, and ADM-IR is associated with the magnitude of RV pressure and myocyte size, suggesting an important role for ventricular ADM in the counteraction against overload as well as in the progress of myocyte hypertrophy after heart transplantation.

AB - Adrenomedullin (ADM) is a vasoactive and natriuretic peptide. While it is known that ADM is increased in failing human ventricles, the expression of ADM in human ventricular allografts remains unknown. The present study was designed to investigate tissue localization and intensity of ADM expression in ventricular biopsy specimens and to characterize ventricular ADM in human cardiac allografts. Thirty-three post-transplant endomyocardial biopsy specimens were examined immunohistochemically. The average score (range: 0-4) of ADM immunoreactivity (IR) was 2.4±0.9 (mean±standard deviation). Right ventricular (RV) systolic pressure was significantly increased with high ADM-IR (p=0.048) and the ADM-IR positively associated with myocyte size (r2=0.23, p=0.010). In contrast, ADM-IR was not associated with systemic blood pressure, serum creatinine, cyclosporine concentration, cardiac fibrosis, or allograft rejection. The present study shows that ADM-IR is present in human ventricular endomyocardium after transplantation, and ADM-IR is associated with the magnitude of RV pressure and myocyte size, suggesting an important role for ventricular ADM in the counteraction against overload as well as in the progress of myocyte hypertrophy after heart transplantation.

KW - Adrenomedullin

KW - Heart transplantation

KW - Human

KW - Hypertrophy

KW - Rejection

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U2 - 10.1016/S0167-0115(03)00035-1

DO - 10.1016/S0167-0115(03)00035-1

M3 - Article

C2 - 12667638

AN - SCOPUS:10744219927

SN - 0167-0115

VL - 112

SP - 161

EP - 166

JO - Regulatory Peptides

JF - Regulatory Peptides

IS - 1-3

ER -

Ventricular adrenomedullin is associated with myocyte hypertrophy in human transplanted heart

Abstract

Bibliographical note

Keywords

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