Vasopressin in the septal area of the golden hamster controls scent marking and grooming

Robert W. Irvin; Patricia Szot; Daniel M. Dorsa; Michael Potegal; Craig F. Ferris

doi:10.1016/0031-9384(90)90213-N

Vasopressin in the septal area of the golden hamster controls scent marking and grooming

Robert W. Irvin, Patricia Szot, Daniel M. Dorsa, Michael Potegal, Craig F. Ferris

Occupational Therapy

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Abstract

Microinjection of arginine vasopressin into the lateral septum and bed nucleus of the stria terminalis of male hamsters stimulates intense flank marking and flank gland grooming, while microinjections of vasopressin in sites immediately adjacent to these areas or in the lateral ventricle are ineffective. Microinjections of oxytocin, angiotensin II and the behaviorally active C-terminal fragment of vasopressin, metabolite neuropeptide, by comparison, do not stimulate flank marking. Effective sites for vasopressin injection are clearly superimposable upon autoradiographically defined sites of high V1-receptor density. Furthermore, vasopressin-sensitive neurons in the lateral septum and bed nucleus of the stria terminalis are necessary for the expression of naturally elicited flank marking since the microinjection of a V1-receptor antagonist into these sites was able to temporarily block flank marking triggered by odors from conspecifics.

Original language	English (US)
Pages (from-to)	693-699
Number of pages	7
Journal	Physiology and Behavior
Volume	48
Issue number	5
DOIs	https://doi.org/10.1016/0031-9384(90)90213-N
State	Published - Nov 1990

Bibliographical note

Funding Information:
This work was supported by NIH grant NS23557 (C.F.F.), NS20311 and the Veterans Administration (D.M.D.), BRSG grant E851U9 from the Research Foundation for Mental Hygiene (M.P.) and NIH National Research Service Award 1 F32 A605456-01 from the National Institute on Aging (P.S.). We thank Judith Allardice for her secretarial assistance.

Keywords

Autoradiography
Flank marking
Oxytocin
Thermoregulation
V1-receptor
Vasopressin receptor antagonist

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10.1016/0031-9384(90)90213-N

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title = "Vasopressin in the septal area of the golden hamster controls scent marking and grooming",

abstract = "Microinjection of arginine vasopressin into the lateral septum and bed nucleus of the stria terminalis of male hamsters stimulates intense flank marking and flank gland grooming, while microinjections of vasopressin in sites immediately adjacent to these areas or in the lateral ventricle are ineffective. Microinjections of oxytocin, angiotensin II and the behaviorally active C-terminal fragment of vasopressin, metabolite neuropeptide, by comparison, do not stimulate flank marking. Effective sites for vasopressin injection are clearly superimposable upon autoradiographically defined sites of high V1-receptor density. Furthermore, vasopressin-sensitive neurons in the lateral septum and bed nucleus of the stria terminalis are necessary for the expression of naturally elicited flank marking since the microinjection of a V1-receptor antagonist into these sites was able to temporarily block flank marking triggered by odors from conspecifics.",

keywords = "Autoradiography, Flank marking, Oxytocin, Thermoregulation, V1-receptor, Vasopressin receptor antagonist",

author = "Irvin, {Robert W.} and Patricia Szot and Dorsa, {Daniel M.} and Michael Potegal and Ferris, {Craig F.}",

note = "Funding Information: This work was supported by NIH grant NS23557 (C.F.F.), NS20311 and the Veterans Administration (D.M.D.), BRSG grant E851U9 from the Research Foundation for Mental Hygiene (M.P.) and NIH National Research Service Award 1 F32 A605456-01 from the National Institute on Aging (P.S.). We thank Judith Allardice for her secretarial assistance.",

year = "1990",

month = nov,

doi = "10.1016/0031-9384(90)90213-N",

language = "English (US)",

volume = "48",

pages = "693--699",

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T1 - Vasopressin in the septal area of the golden hamster controls scent marking and grooming

AU - Irvin, Robert W.

AU - Szot, Patricia

AU - Dorsa, Daniel M.

AU - Potegal, Michael

AU - Ferris, Craig F.

N1 - Funding Information: This work was supported by NIH grant NS23557 (C.F.F.), NS20311 and the Veterans Administration (D.M.D.), BRSG grant E851U9 from the Research Foundation for Mental Hygiene (M.P.) and NIH National Research Service Award 1 F32 A605456-01 from the National Institute on Aging (P.S.). We thank Judith Allardice for her secretarial assistance.

PY - 1990/11

Y1 - 1990/11

N2 - Microinjection of arginine vasopressin into the lateral septum and bed nucleus of the stria terminalis of male hamsters stimulates intense flank marking and flank gland grooming, while microinjections of vasopressin in sites immediately adjacent to these areas or in the lateral ventricle are ineffective. Microinjections of oxytocin, angiotensin II and the behaviorally active C-terminal fragment of vasopressin, metabolite neuropeptide, by comparison, do not stimulate flank marking. Effective sites for vasopressin injection are clearly superimposable upon autoradiographically defined sites of high V1-receptor density. Furthermore, vasopressin-sensitive neurons in the lateral septum and bed nucleus of the stria terminalis are necessary for the expression of naturally elicited flank marking since the microinjection of a V1-receptor antagonist into these sites was able to temporarily block flank marking triggered by odors from conspecifics.

AB - Microinjection of arginine vasopressin into the lateral septum and bed nucleus of the stria terminalis of male hamsters stimulates intense flank marking and flank gland grooming, while microinjections of vasopressin in sites immediately adjacent to these areas or in the lateral ventricle are ineffective. Microinjections of oxytocin, angiotensin II and the behaviorally active C-terminal fragment of vasopressin, metabolite neuropeptide, by comparison, do not stimulate flank marking. Effective sites for vasopressin injection are clearly superimposable upon autoradiographically defined sites of high V1-receptor density. Furthermore, vasopressin-sensitive neurons in the lateral septum and bed nucleus of the stria terminalis are necessary for the expression of naturally elicited flank marking since the microinjection of a V1-receptor antagonist into these sites was able to temporarily block flank marking triggered by odors from conspecifics.

KW - Autoradiography

KW - Flank marking

KW - Oxytocin

KW - Thermoregulation

KW - V1-receptor

KW - Vasopressin receptor antagonist

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JO - Physiology and Behavior

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ER -

Vasopressin in the septal area of the golden hamster controls scent marking and grooming

Abstract

Bibliographical note

Keywords

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