Vasomotor symptoms of menopause, autonomic dysfunction, and cardiovascular disease

Emma Lee, Miguel Anselmo, Chowdhury Tasnova Tahsin, Marnie Vanden Noven, William Stokes, Jason R. Carter, Manda L. Keller-Ross

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Cardiovascular disease (CVD), the leading cause of death among US adults, is more prevalent in menopausal females compared with age-matched males. Vasomotor symptoms of menopause (VMS; hot flashes/flushes and night sweats) are common among females undergoing menopausal transition and have been associated with elevated blood pressure (BP) and increased CVD risk. Autonomic dysregulation of BP has been posited as a contributing factor to the elevated CVD risk in menopausal females with VMS. This review includes 1) a brief overview of the relationship between VMS and CVD, 2) mechanisms of hot flushes and their potential impact on short- and long-term BP regulation, and 3) how the disruption of autonomic function associated with VMS might provide a mechanistic pathway to CVD development. Finally, this review will highlight knowledge gaps and future directions toward better understanding of hot flush physiology and VMS contributions to CVD.

Original languageEnglish (US)
Pages (from-to)H1270-H1280
JournalAmerican journal of physiology. Heart and circulatory physiology
Issue number6
StatePublished - Dec 1 2022


  • blood pressure
  • hot flushes
  • menopause
  • night sweats
  • sex differences

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural


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