Vasodilator Therapy of Cardiac Failure

Jan Koch-Weser, Jay N Cohn, Joseph A. Franciosa

Research output: Contribution to journalReview articlepeer-review

188 Scopus citations


(Second of Two Parts)* Acute Myocardial Infarction Vasodilator therapy has been advocated for two purposes in patients with acute myocardial infarction: improvement in pump function; and reduction in myocardial ischemia. Pump Function Left ventricular dysfunction in acute myocardial infarction is characterized by a high left ventricular diastolic pressure and a low stroke volume.32 Since the left ventricle usually is not much dilated despite the high filling pressure some of the rise in pressure has been attributed to a reduction in diastolic compliance.33 Clinical signs of left ventricular failure often coexist with the hemodynamic derangement, but sometimes the lungs are clear.

Original languageEnglish (US)
Pages (from-to)254-258
Number of pages5
JournalNew England Journal of Medicine
Issue number5
StatePublished - Aug 4 1977


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