VASOCONSTRICTOR DRUG EFFECTS ON VASCULAR COMPLIANCE BY PULSE CONTOUR ANALYSIS.

J. Mock, S. M. Finkelstein, J. B. Eaton, G. Hatfield, Jay N Cohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

The effect of the vasoconstrictors norepinephrine (NE) and angiotensin (AT) on vascular compliance in dogs was studied using pulse contour analysis (PCA). The femoral arterial pressure waveform was recorded. Resistance was determined from measured mean arterial pressure (MAP) and cardiac output (CO), obtained via thermodilution. The beginning of systole, diastole, and the end of diastole were manually marked on ten consecutive beats. A Gauss-Newton parameter-estimation algorithm calculated the Ai (i equals 1,. . . ,6) coefficients for the third-order function representing the femoral artery pressure. MAP, CO A2, A4 and A5 were then used to obtain vascular resistance and proximal and distal compliances. Measurements were made in the control state and during NE infusion and repeated in a recontrol period and during AT infusion. Vascular response to each vasoconstrictor was determined by the paired t-test, with each dog serving as its own control.

Original languageEnglish (US)
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
PublisherIEEE
Pages878-879
Number of pages2
StatePublished - Dec 1 1987

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Norepinephrine
Parameter estimation
Compliance

Cite this

Mock, J., Finkelstein, S. M., Eaton, J. B., Hatfield, G., & Cohn, J. N. (1987). VASOCONSTRICTOR DRUG EFFECTS ON VASCULAR COMPLIANCE BY PULSE CONTOUR ANALYSIS. In IEEE/Engineering in Medicine and Biology Society Annual Conference (pp. 878-879). IEEE.

VASOCONSTRICTOR DRUG EFFECTS ON VASCULAR COMPLIANCE BY PULSE CONTOUR ANALYSIS. / Mock, J.; Finkelstein, S. M.; Eaton, J. B.; Hatfield, G.; Cohn, Jay N.

IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, 1987. p. 878-879.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mock, J, Finkelstein, SM, Eaton, JB, Hatfield, G & Cohn, JN 1987, VASOCONSTRICTOR DRUG EFFECTS ON VASCULAR COMPLIANCE BY PULSE CONTOUR ANALYSIS. in IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, pp. 878-879.
Mock J, Finkelstein SM, Eaton JB, Hatfield G, Cohn JN. VASOCONSTRICTOR DRUG EFFECTS ON VASCULAR COMPLIANCE BY PULSE CONTOUR ANALYSIS. In IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE. 1987. p. 878-879
Mock, J. ; Finkelstein, S. M. ; Eaton, J. B. ; Hatfield, G. ; Cohn, Jay N. / VASOCONSTRICTOR DRUG EFFECTS ON VASCULAR COMPLIANCE BY PULSE CONTOUR ANALYSIS. IEEE/Engineering in Medicine and Biology Society Annual Conference. IEEE, 1987. pp. 878-879
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abstract = "The effect of the vasoconstrictors norepinephrine (NE) and angiotensin (AT) on vascular compliance in dogs was studied using pulse contour analysis (PCA). The femoral arterial pressure waveform was recorded. Resistance was determined from measured mean arterial pressure (MAP) and cardiac output (CO), obtained via thermodilution. The beginning of systole, diastole, and the end of diastole were manually marked on ten consecutive beats. A Gauss-Newton parameter-estimation algorithm calculated the Ai (i equals 1,. . . ,6) coefficients for the third-order function representing the femoral artery pressure. MAP, CO A2, A4 and A5 were then used to obtain vascular resistance and proximal and distal compliances. Measurements were made in the control state and during NE infusion and repeated in a recontrol period and during AT infusion. Vascular response to each vasoconstrictor was determined by the paired t-test, with each dog serving as its own control.",
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N2 - The effect of the vasoconstrictors norepinephrine (NE) and angiotensin (AT) on vascular compliance in dogs was studied using pulse contour analysis (PCA). The femoral arterial pressure waveform was recorded. Resistance was determined from measured mean arterial pressure (MAP) and cardiac output (CO), obtained via thermodilution. The beginning of systole, diastole, and the end of diastole were manually marked on ten consecutive beats. A Gauss-Newton parameter-estimation algorithm calculated the Ai (i equals 1,. . . ,6) coefficients for the third-order function representing the femoral artery pressure. MAP, CO A2, A4 and A5 were then used to obtain vascular resistance and proximal and distal compliances. Measurements were made in the control state and during NE infusion and repeated in a recontrol period and during AT infusion. Vascular response to each vasoconstrictor was determined by the paired t-test, with each dog serving as its own control.

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