TY - JOUR
T1 - Vascular variability anomalies (VVAs) in children
AU - Syutkina, Elena Vasiljevna
AU - Kozhevnikova, Olga Viktorovna
AU - Namazova-Baranova, Leila Seimurovna
AU - Smirnov, Ivan Jevgenievitch
AU - Masalov, Anatoly Viktorovich
AU - Cornelissen, Germaine
AU - Schwartzkopff, Othild
AU - Mitish, Maria Dmitrijevna
AU - Gumarova, Lyazzat
AU - Halberg, Franz
N1 - Publisher Copyright:
© 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - This work aims at studying in children the prevalence of some vascular variability anomalies (VVAs), i.e. indices of an increased risk of heart and vessel diseases revealed by chronobiologic analysis of cardiovascular monitoring data - systolic (SBP) and diastolic (DBP) MESOR-hyper- tension/hypotension, circadian hyper-amplitude-tension (CHAT), ecphasia and an excessive pulse pressure (EPP). A reference group of 138 healthy Moscow schoolchildren (age 12-17 years) was used for determination of 90% prediction limits for the circadian parameters of SBP and DBP, specified by gender and age (or height). The test group included another 194 children of the same age range with headache and abnormal BP values by casual measurement. BP data series from each child were analyzed by the COSINOR method. VVAs were found in 44.8% of children from the test group. In boys, VVAs occur more often than in girls (51.5% vs. 30.6%). One child may have up to 3 VVAs. The presence of VVAs may be related to an elevated BMI. The most common VVAs in childhood are the abnormalities of PP and systolic CHAT. Cosinor analysis can reveal a large number of children with PP higher than a threshold (60 mmHg) during a relatively long portion of the day (more than 1/3 of the 24 h span).
AB - This work aims at studying in children the prevalence of some vascular variability anomalies (VVAs), i.e. indices of an increased risk of heart and vessel diseases revealed by chronobiologic analysis of cardiovascular monitoring data - systolic (SBP) and diastolic (DBP) MESOR-hyper- tension/hypotension, circadian hyper-amplitude-tension (CHAT), ecphasia and an excessive pulse pressure (EPP). A reference group of 138 healthy Moscow schoolchildren (age 12-17 years) was used for determination of 90% prediction limits for the circadian parameters of SBP and DBP, specified by gender and age (or height). The test group included another 194 children of the same age range with headache and abnormal BP values by casual measurement. BP data series from each child were analyzed by the COSINOR method. VVAs were found in 44.8% of children from the test group. In boys, VVAs occur more often than in girls (51.5% vs. 30.6%). One child may have up to 3 VVAs. The presence of VVAs may be related to an elevated BMI. The most common VVAs in childhood are the abnormalities of PP and systolic CHAT. Cosinor analysis can reveal a large number of children with PP higher than a threshold (60 mmHg) during a relatively long portion of the day (more than 1/3 of the 24 h span).
KW - Blood pressure monitoring
KW - Cardiovascular disease risk
KW - Children
KW - Chronobiologic analysis
KW - Vascular variability anomalies
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U2 - 10.1016/j.jab.2014.02.004
DO - 10.1016/j.jab.2014.02.004
M3 - Article
AN - SCOPUS:84961289847
SN - 1214-021X
VL - 12
SP - 147
EP - 153
JO - Journal of Applied Biomedicine
JF - Journal of Applied Biomedicine
IS - 3
ER -
