Vascular Structure and Function in Cancer Survivors after Hematopoietic Stem Cell Transplantation

Donald R Dengel, Aaron S Kelly, Lei Zhang, Qi Wang, James S Hodges, Julia Steinberger, K. Scott Baker

Research output: Contribution to journalArticle

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Abstract

This study examined the effects of hematopoietic cell transplantation (HCT) and associated preparative regimens on vascular structure and function. Measures of carotid artery stiffness and brachial artery endothelial-dependent dilation were obtained in patients who had survived ≥ 2 years after HCT for hematologic malignancy and were diagnosed at ≤21 years. HCT survivors (n = 108) were examined: 66 received total body irradiation (TBI) alone or with a low-dose cranial radiation boost (TBI±LD-CRT), 19 received TBI plus high-dose cranial radiation (TBI+HD-CRT), and 23 received a chemotherapy-only preparative regimen (CHEMO). Siblings (n = 83) were invited to participate as control subjects. Although endothelial-dependent dilation did not differ between siblings and HCT survivors, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, and diameter distensibility were greater in siblings than HCT survivors. Comparing the HCT preparative regimens, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, diameter distensibility, and incremental elastic modulus were significantly lower in the TBI+HD-CRT group compared with siblings or with TBI±LD-CRT and CHEMO treatment groups. Cross-sectional distensibility and diameter compliance were significantly lower in the TBI±LD-CRT group compared with siblings. TBI±LD-CRT and CHEMO groups did not differ from each other in these vascular measures. HCT preparative regimens containing TBI+HD-CRT resulted in greater arterial decrements, indicating increased risk for cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2019

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Hematopoietic Stem Cell Transplantation
Cell Transplantation
Blood Vessels
Survivors
Whole-Body Irradiation
Compliance
Siblings
Neoplasms
Drug Therapy
Dilatation
Radiation
Brachial Artery
Elastic Modulus
Hematologic Neoplasms
Carotid Arteries
Cardiovascular Diseases

Keywords

  • Cancer survivors
  • Compliance
  • Distensibility
  • Endothelial function
  • Ultrasound

Cite this

Vascular Structure and Function in Cancer Survivors after Hematopoietic Stem Cell Transplantation. / Dengel, Donald R; Kelly, Aaron S; Zhang, Lei; Wang, Qi; Hodges, James S; Steinberger, Julia; Baker, K. Scott.

In: Biology of Blood and Marrow Transplantation, Vol. 25, No. 1, 01.01.2019, p. 151-156.

Research output: Contribution to journalArticle

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