Vascular smooth muscle remodeling in conductive and resistance arteries in hypertension

Isola A.M. Brown, Lukas Diederich, Miranda E. Good, Leon J. DeLalio, Sara A. Murphy, Miriam M. Cortese-Krott, Jennifer L. Hall, Thu H. Le, Brant E. Isakson

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Cardiovascular disease is a leading cause of death worldwide and accounts for >17.3 million deaths per year, with an estimated increase in incidence to 23.6 million by 2030.1 Cardiovascular death represents 31% of all global deaths2-with stroke, heart attack, and ruptured aneurysms predominantly contributing to these high mortality rates. A key risk factor for cardiovascular disease is hypertension. Although treatment or reduction in hypertension can prevent the onset of cardiovascular events, existing therapies are only partially effective. A key pathological hallmark of hypertension is increased peripheral vascular resistance because of structural and functional changes in large (conductive) and small (resistance) arteries. In this review, we discuss the clinical implications of vascular remodeling, compare the differences between vascular smooth muscle cell remodeling in conductive and resistance arteries, discuss the genetic factors associated with vascular smooth muscle cell function in hypertensive patients, and provide a prospective assessment of current and future research and pharmacological targets for the treatment of hypertension.

Original languageEnglish (US)
Pages (from-to)1969-1985
Number of pages17
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number9
StatePublished - 2018

Bibliographical note

Funding Information:
This study was supported by National Institutes of Health grants HL088554 (B.E. Isakson), HL120840 (B.E. Isakson), and DK113632 (T.H. Le).

Publisher Copyright:
© 2018 American Heart Association, Inc.


  • Hypertension
  • Myocardial infarction
  • Smooth muscle
  • Vascular remodeling


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