Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network

Thaddeus J. Haight; R. Nick Bryan; Guray Erus; Christos Davatzikos; David R. Jacobs; Mark D'Esposito; Cora E. Lewis; Lenore J. Launer

doi:10.1016/j.neuroimage.2015.04.039

Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network

Thaddeus J. Haight, R. Nick Bryan, Guray Erus, Christos Davatzikos, David R. Jacobs, Mark D'Esposito, Cora E. Lewis, Lenore J. Launer

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Cumulating evidence from epidemiologic studies implicates cardiovascular health and cerebrovascular function in several brain diseases in late life. We examined vascular risk factors with respect to a cerebrovascular measure of brain functioning in subjects in mid-life, which could represent a marker of brain changes in later life. Breath-hold functional MRI (fMRI) was performed in 541 women and men (mean age 50.4. years) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study. Cerebrovascular reactivity (CVR) was quantified as percentage change in blood-oxygen level dependent (BOLD) signal in activated voxels, which was mapped to a common brain template and log-transformed. Mean CVR was calculated for anatomic regions underlying the default-mode network (DMN) - a network implicated in AD and other brain disorders - in addition to areas considered to be relatively spared in the disease (e.g. occipital lobe), which were utilized as reference regions. Mean CVR was significantly reduced in the posterior cingulate/precuneus (β. =. -. 0.063, 95% CI: -. 0.106, -. 0.020), anterior cingulate (β. =. -. 0.055, 95% CI: -. 0.101, -. 0.010), and medial frontal lobe (β. =. -. 0.050, 95% CI: -. 0.092, -. 0.008) relative to mean CVR in the occipital lobe, after adjustment for age, sex, race, education, and smoking status, in subjects with pre-hypertension/hypertension compared to normotensive subjects. By contrast, mean CVR was lower, but not significantly, in the inferior parietal lobe (β. =. -. 0.024, 95% CI: -. 0.062, 0.014) and the hippocampus (β. =. -. 0.006, 95% CI: -. 0.062, 0.050) relative to mean CVR in the occipital lobe. Similar results were observed in subjects with diabetes and dyslipidemia compared to those without these conditions, though the differences were non-significant. Reduced CVR may represent diminished vascular functionality for the DMN for individuals with prehypertension/hypertension in mid-life, and may serve as a preclinical marker for brain dysfunction in later life.

Original language	English (US)
Pages (from-to)	7-16
Number of pages	10
Journal	NeuroImage
Volume	115
DOIs	https://doi.org/10.1016/j.neuroimage.2015.04.039
State	Published - Jul 5 2015

Bibliographical note

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C , HHSN268201300026C , HHSN268201300027C , HHSN268201300028C , HHSN268201300029C , and HHSN268200900041C from the National Heart, Lung, and Blood Institute (NHLBI) , the Intramural Research Program of the National Institute on Aging (NIA) , and an intra-agency agreement between NIA and NHLBI ( AG0005 ).

Publisher Copyright:
© 2015 Elsevier Inc.

Keywords

Alzheimer's disease
Neurophysiology
Vascular risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.neuroimage.2015.04.039

Find It

Find It at U of M Libraries

Cite this

@article{e8abb918532a4d298202388b5962c9e4,

title = "Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network",

abstract = "Cumulating evidence from epidemiologic studies implicates cardiovascular health and cerebrovascular function in several brain diseases in late life. We examined vascular risk factors with respect to a cerebrovascular measure of brain functioning in subjects in mid-life, which could represent a marker of brain changes in later life. Breath-hold functional MRI (fMRI) was performed in 541 women and men (mean age 50.4. years) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study. Cerebrovascular reactivity (CVR) was quantified as percentage change in blood-oxygen level dependent (BOLD) signal in activated voxels, which was mapped to a common brain template and log-transformed. Mean CVR was calculated for anatomic regions underlying the default-mode network (DMN) - a network implicated in AD and other brain disorders - in addition to areas considered to be relatively spared in the disease (e.g. occipital lobe), which were utilized as reference regions. Mean CVR was significantly reduced in the posterior cingulate/precuneus (β. =. -. 0.063, 95% CI: -. 0.106, -. 0.020), anterior cingulate (β. =. -. 0.055, 95% CI: -. 0.101, -. 0.010), and medial frontal lobe (β. =. -. 0.050, 95% CI: -. 0.092, -. 0.008) relative to mean CVR in the occipital lobe, after adjustment for age, sex, race, education, and smoking status, in subjects with pre-hypertension/hypertension compared to normotensive subjects. By contrast, mean CVR was lower, but not significantly, in the inferior parietal lobe (β. =. -. 0.024, 95% CI: -. 0.062, 0.014) and the hippocampus (β. =. -. 0.006, 95% CI: -. 0.062, 0.050) relative to mean CVR in the occipital lobe. Similar results were observed in subjects with diabetes and dyslipidemia compared to those without these conditions, though the differences were non-significant. Reduced CVR may represent diminished vascular functionality for the DMN for individuals with prehypertension/hypertension in mid-life, and may serve as a preclinical marker for brain dysfunction in later life.",

keywords = "Alzheimer's disease, Neurophysiology, Vascular risk factors",

author = "Haight, {Thaddeus J.} and Bryan, {R. Nick} and Guray Erus and Christos Davatzikos and Jacobs, {David R.} and Mark D'Esposito and Lewis, {Cora E.} and Launer, {Lenore J.}",

note = "Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C , HHSN268201300026C , HHSN268201300027C , HHSN268201300028C , HHSN268201300029C , and HHSN268200900041C from the National Heart, Lung, and Blood Institute (NHLBI) , the Intramural Research Program of the National Institute on Aging (NIA) , and an intra-agency agreement between NIA and NHLBI ( AG0005 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = jul,

day = "5",

doi = "10.1016/j.neuroimage.2015.04.039",

language = "English (US)",

volume = "115",

pages = "7--16",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network

AU - Haight, Thaddeus J.

AU - Bryan, R. Nick

AU - Erus, Guray

AU - Davatzikos, Christos

AU - Jacobs, David R.

AU - D'Esposito, Mark

AU - Lewis, Cora E.

AU - Launer, Lenore J.

N1 - Funding Information: The Coronary Artery Risk Development in Young Adults Study (CARDIA) is supported by contracts HHSN268201300025C , HHSN268201300026C , HHSN268201300027C , HHSN268201300028C , HHSN268201300029C , and HHSN268200900041C from the National Heart, Lung, and Blood Institute (NHLBI) , the Intramural Research Program of the National Institute on Aging (NIA) , and an intra-agency agreement between NIA and NHLBI ( AG0005 ). Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/7/5

Y1 - 2015/7/5

N2 - Cumulating evidence from epidemiologic studies implicates cardiovascular health and cerebrovascular function in several brain diseases in late life. We examined vascular risk factors with respect to a cerebrovascular measure of brain functioning in subjects in mid-life, which could represent a marker of brain changes in later life. Breath-hold functional MRI (fMRI) was performed in 541 women and men (mean age 50.4. years) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study. Cerebrovascular reactivity (CVR) was quantified as percentage change in blood-oxygen level dependent (BOLD) signal in activated voxels, which was mapped to a common brain template and log-transformed. Mean CVR was calculated for anatomic regions underlying the default-mode network (DMN) - a network implicated in AD and other brain disorders - in addition to areas considered to be relatively spared in the disease (e.g. occipital lobe), which were utilized as reference regions. Mean CVR was significantly reduced in the posterior cingulate/precuneus (β. =. -. 0.063, 95% CI: -. 0.106, -. 0.020), anterior cingulate (β. =. -. 0.055, 95% CI: -. 0.101, -. 0.010), and medial frontal lobe (β. =. -. 0.050, 95% CI: -. 0.092, -. 0.008) relative to mean CVR in the occipital lobe, after adjustment for age, sex, race, education, and smoking status, in subjects with pre-hypertension/hypertension compared to normotensive subjects. By contrast, mean CVR was lower, but not significantly, in the inferior parietal lobe (β. =. -. 0.024, 95% CI: -. 0.062, 0.014) and the hippocampus (β. =. -. 0.006, 95% CI: -. 0.062, 0.050) relative to mean CVR in the occipital lobe. Similar results were observed in subjects with diabetes and dyslipidemia compared to those without these conditions, though the differences were non-significant. Reduced CVR may represent diminished vascular functionality for the DMN for individuals with prehypertension/hypertension in mid-life, and may serve as a preclinical marker for brain dysfunction in later life.

AB - Cumulating evidence from epidemiologic studies implicates cardiovascular health and cerebrovascular function in several brain diseases in late life. We examined vascular risk factors with respect to a cerebrovascular measure of brain functioning in subjects in mid-life, which could represent a marker of brain changes in later life. Breath-hold functional MRI (fMRI) was performed in 541 women and men (mean age 50.4. years) from the Coronary Artery Risk Development in Young Adults (CARDIA) Brain MRI sub-study. Cerebrovascular reactivity (CVR) was quantified as percentage change in blood-oxygen level dependent (BOLD) signal in activated voxels, which was mapped to a common brain template and log-transformed. Mean CVR was calculated for anatomic regions underlying the default-mode network (DMN) - a network implicated in AD and other brain disorders - in addition to areas considered to be relatively spared in the disease (e.g. occipital lobe), which were utilized as reference regions. Mean CVR was significantly reduced in the posterior cingulate/precuneus (β. =. -. 0.063, 95% CI: -. 0.106, -. 0.020), anterior cingulate (β. =. -. 0.055, 95% CI: -. 0.101, -. 0.010), and medial frontal lobe (β. =. -. 0.050, 95% CI: -. 0.092, -. 0.008) relative to mean CVR in the occipital lobe, after adjustment for age, sex, race, education, and smoking status, in subjects with pre-hypertension/hypertension compared to normotensive subjects. By contrast, mean CVR was lower, but not significantly, in the inferior parietal lobe (β. =. -. 0.024, 95% CI: -. 0.062, 0.014) and the hippocampus (β. =. -. 0.006, 95% CI: -. 0.062, 0.050) relative to mean CVR in the occipital lobe. Similar results were observed in subjects with diabetes and dyslipidemia compared to those without these conditions, though the differences were non-significant. Reduced CVR may represent diminished vascular functionality for the DMN for individuals with prehypertension/hypertension in mid-life, and may serve as a preclinical marker for brain dysfunction in later life.

KW - Alzheimer's disease

KW - Neurophysiology

KW - Vascular risk factors

UR - http://www.scopus.com/inward/record.url?scp=84928888984&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928888984&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2015.04.039

DO - 10.1016/j.neuroimage.2015.04.039

M3 - Article

C2 - 25917517

AN - SCOPUS:84928888984

SN - 1053-8119

VL - 115

SP - 7

EP - 16

JO - NeuroImage

JF - NeuroImage

ER -

Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this