Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Biologically-engineered matrix - a tissue that is grown in vitro from donor cells, decellularized, and stored prior to use as off-the-shelf allografts - offers a promising alternative to current cardiovascular biomaterials. This perspective reviews preclinical studies and clinical trials of vascular grafts and valves comprising biologically-engineered matrix, with a focus on those based on donor dermal fibroblast remodeling of fibrin gel with the capacity to heal and grow following recellularization, via animation of the matrix. It concludes with a discussion of related key clinical considerations.

Original languageEnglish (US)
Pages (from-to)577-585
Number of pages9
JournalJournal of Cardiovascular Surgery
Volume61
Issue number5
DOIs
StatePublished - Oct 2020

Bibliographical note

Publisher Copyright:
© 2020 EDIZIONI MINERV AMEDICA

Keywords

  • Bioengineering
  • Heart valve
  • Regenerative medicine
  • Tissue engineering
  • Vascular grafting
  • Venous valves

PubMed: MeSH publication types

  • Journal Article
  • Review

Fingerprint

Dive into the research topics of 'Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes'. Together they form a unique fingerprint.

Cite this