Vascular Composite Allografts (VCA): New Transplants, New Infections

Julie M. Steinbrink; Timothy L. Pruett; Linda C. Cendales

doi:10.1007/978-3-030-25869-6_61

Vascular Composite Allografts (VCA): New Transplants, New Infections

Julie M. Steinbrink, Timothy L. Pruett, Linda C. Cendales

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Vascularized composite allografts, or VCA transplants, are allotransplants that incorporate multiple tissues transplanted as a single functional unit, most commonly hands or face. They are, by definition, transplants aimed at improving quality of life rather than life sparing. Yet they may also be life-giving in the case of temporary uterine transplants, where the goal is to carry a healthy pregnancy through to term and delivery. Because of the multiple tissue layers involved and the systemic immunosuppression required to prevent rejection, VCA transplants carry unique infection risks, distinct for each tissue in VCA. By understanding the different infectious risks carried by different tissues, this chapter builds a framework to understand and evaluate infection of any vascularized composite allograft.

Original language	English (US)
Title of host publication	Emerging Transplant Infections
Subtitle of host publication	Clinical Challenges and Implications
Publisher	Springer International Publishing
Pages	1513-1532
Number of pages	20
ISBN (Electronic)	9783030258696
ISBN (Print)	9783030258689
DOIs	https://doi.org/10.1007/978-3-030-25869-6_61
State	Published - Jan 1 2021

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2021.

Keywords

Composite allograft
Face transplant
Hand transplant
Uterine transplant
VCA

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10.1007/978-3-030-25869-6_61

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abstract = "Vascularized composite allografts, or VCA transplants, are allotransplants that incorporate multiple tissues transplanted as a single functional unit, most commonly hands or face. They are, by definition, transplants aimed at improving quality of life rather than life sparing. Yet they may also be life-giving in the case of temporary uterine transplants, where the goal is to carry a healthy pregnancy through to term and delivery. Because of the multiple tissue layers involved and the systemic immunosuppression required to prevent rejection, VCA transplants carry unique infection risks, distinct for each tissue in VCA. By understanding the different infectious risks carried by different tissues, this chapter builds a framework to understand and evaluate infection of any vascularized composite allograft.",

keywords = "Composite allograft, Face transplant, Hand transplant, Uterine transplant, VCA",

author = "Steinbrink, {Julie M.} and Pruett, {Timothy L.} and Cendales, {Linda C.}",

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doi = "10.1007/978-3-030-25869-6_61",

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AU - Steinbrink, Julie M.

AU - Pruett, Timothy L.

AU - Cendales, Linda C.

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2021.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Vascularized composite allografts, or VCA transplants, are allotransplants that incorporate multiple tissues transplanted as a single functional unit, most commonly hands or face. They are, by definition, transplants aimed at improving quality of life rather than life sparing. Yet they may also be life-giving in the case of temporary uterine transplants, where the goal is to carry a healthy pregnancy through to term and delivery. Because of the multiple tissue layers involved and the systemic immunosuppression required to prevent rejection, VCA transplants carry unique infection risks, distinct for each tissue in VCA. By understanding the different infectious risks carried by different tissues, this chapter builds a framework to understand and evaluate infection of any vascularized composite allograft.

AB - Vascularized composite allografts, or VCA transplants, are allotransplants that incorporate multiple tissues transplanted as a single functional unit, most commonly hands or face. They are, by definition, transplants aimed at improving quality of life rather than life sparing. Yet they may also be life-giving in the case of temporary uterine transplants, where the goal is to carry a healthy pregnancy through to term and delivery. Because of the multiple tissue layers involved and the systemic immunosuppression required to prevent rejection, VCA transplants carry unique infection risks, distinct for each tissue in VCA. By understanding the different infectious risks carried by different tissues, this chapter builds a framework to understand and evaluate infection of any vascularized composite allograft.

KW - Composite allograft

KW - Face transplant

KW - Hand transplant

KW - Uterine transplant

KW - VCA

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Vascular Composite Allografts (VCA): New Transplants, New Infections

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