Varicella in children with renal transplants

Christa M. Feldhoff, Henry H. Balfour, Richard L. Simmons, John S. Najarian, S. Michael Mauer

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113 Scopus citations


Nineteen of 160 children developed varicella between eight days and 6.4 years following renal transplantation. Eight had severe varicella characterized by prolonged fever and new vesicle formation with rash involving mucous membranes. The severe group had an increased incidence of thrombocytopenia and markedly elevated liver enzyme values. Two patients of this group had bladder paralysis and another died. In three children the post-transplant varicella represented a second attack of this disease. Children maintained on azathioprine therapy for three days or more after onset tended to have severe varicella. No graft loss occurred consequent to stopping azathioprine. Children with transplants at risk should have zoster immune plasma or globulin upon exposure, and azathioprine therapy should be stopped at onset of varicella. Corticosteroid therapy should be continued in order to avoid stress-induced Addisonian crisis.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalThe Journal of pediatrics
Issue number1
StatePublished - Jan 1981

Bibliographical note

Funding Information:
From the Departments of Pediatrics, Laboratory Medicine and Pathology, Surgery, and Microbiology, University of Minnesota. Supported in part by United States Public Health Service grants AM 13083 and 18883. *Reprint address: Department of Pediatrics, Mayo Box 491, University of Minnesota Hospitals, 420 Delaware St., S.E., Minneapolis, MN 55455.


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