Variation in the incidence of renal adenocarcinoma among Rana pipiens held under tumor-promoting conditions

Robert G. McKinnell, Eville Gorham, Dean G. Binger

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In 1975-1976, significant differences were observed in the frequencies of renal tumors in wild-caught frogs from different sites when they were held in the laboratory under tumor-promoting conditions. In 1979-1980, tumors could not be induced in frogs from a site where spontaneous tumors were no longer detectable. It is suggested that because spontaneous tumors have decreased in natural populations, it is less likely that the etiologic agent - the Lucke-tumor herpesvirus - will be present to promote tumor development under the stress of laboratory conditions.
Original languageUndefined/Unknown
Pages (from-to)111-116
Number of pages6
JournalAmerican Midland Naturalist
Issue number1
StatePublished - 1982


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