Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents

Colin G. Deyoung, Marya Getchell, Roman A. Koposov, Carolyn M. Yrigollen, Gerald J. Haeffel, Britt Af Klinteberg, Lars Oreland, Vladislav V. Ruchkin, Andrew J. Pakstis, Elena L. Grigorenko

    Research output: Contribution to journalArticlepeer-review

    40 Scopus citations

    Abstract

    Objective: Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method: This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results: The Val allele of the ValMet polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion: The ValMet polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.

    Original languageEnglish (US)
    Pages (from-to)20-24
    Number of pages5
    JournalPsychiatric Genetics
    Volume20
    Issue number1
    DOIs
    StatePublished - Feb 2010

    Keywords

    • Antisocial behavior
    • Attention deficit/hyperactivity disorder
    • Catechol-O-methyltransferase
    • Conduct disorder
    • Genetics

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