Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry

Emelia J. Benjamin; Kenneth M. Rice; Dan E. Arking; Arne Pfeufer; Charlotte Van Noord; Albert V. Smith; Renate B. Schnabel; Joshua C. Bis; Eric Boerwinkle; Moritz F. Sinner; Abbas Dehghan; Steven A. Lubitz; Ralph B. D'Agostino; Thomas Lumley; Georg B. Ehret; Jan Heeringa; Thor Aspelund; Christopher Newton-Cheh; Martin G. Larson; Kristin D. Marciante; Elsayed Z. Soliman; Fernando Rivadeneira; Thomas J. Wang; Gudny Eiríksdottir; Daniel Levy; Bruce M. Psaty; Man Li; Alanna M. Chamberlain; Albert Hofman; Ramachandran S. Vasan; Tamara B. Harris; Jerome I. Rotter; W. H Linda Kao; Sunil K. Agarwal; Bruno H Ch Stricker; Ke Wang; Lenore J. Launer; Nicholas L. Smith; Aravinda Chakravarti; André G. Uitterlinden; Philip A. Wolf; Nona Sotoodehnia; Anna Köttgen; Cornelia M. Van Duijn; Thomas Meitinger; Martina Mueller; Siegfried Perz; Gerhard Steinbeck; H. Erich Wichmann; Kathryn L. Lunetta; Susan R. Heckbert; Vilmundur Gudnason; Alvaro Alonso; Stefan Kääb; Patrick T. Ellinor; Jacqueline C M Witteman

doi:10.1038/ng.416

Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry

Emelia J. Benjamin, Kenneth M. Rice, Dan E. Arking, Arne Pfeufer, Charlotte Van Noord, Albert V. Smith, Renate B. Schnabel, Joshua C. Bis, Eric Boerwinkle, Moritz F. Sinner, Abbas Dehghan, Steven A. Lubitz, Ralph B. D'Agostino, Thomas Lumley, Georg B. Ehret, Jan Heeringa, Thor Aspelund, Christopher Newton-Cheh, Martin G. Larson, Kristin D. MarcianteElsayed Z. Soliman, Fernando Rivadeneira, Thomas J. Wang, Gudny Eiríksdottir, Daniel Levy, Bruce M. Psaty, Man Li, Alanna M. Chamberlain, Albert Hofman, Ramachandran S. Vasan, Tamara B. Harris, Jerome I. Rotter, W. H Linda Kao, Sunil K. Agarwal, Bruno H Ch Stricker, Ke Wang, Lenore J. Launer, Nicholas L. Smith, Aravinda Chakravarti, André G. Uitterlinden, Philip A. Wolf, Nona Sotoodehnia, Anna Köttgen, Cornelia M. Van Duijn, Thomas Meitinger, Martina Mueller, Siegfried Perz, Gerhard Steinbeck, H. Erich Wichmann, Kathryn L. Lunetta, Susan R. Heckbert, Vilmundur Gudnason, Alvaro Alonso, Stefan Kääb, Patrick T. Ellinor, Jacqueline C M Witteman

Epidemiology & Community Health

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Abstract

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10^-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 ^-11; combined RR = 1.25; combined P = 1.8 × 10 ^-15).

Original language	English (US)
Pages (from-to)	879-881
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	8
DOIs	https://doi.org/10.1038/ng.416
State	Published - Aug 2009

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Benjamin, E. J., Rice, K. M., Arking, D. E., Pfeufer, A., Van Noord, C., Smith, A. V., Schnabel, R. B., Bis, J. C., Boerwinkle, E., Sinner, M. F., Dehghan, A., Lubitz, S. A., D'Agostino, R. B., Lumley, T., Ehret, G. B., Heeringa, J., Aspelund, T., Newton-Cheh, C., Larson, M. G., ... Witteman, J. C. M. (2009). Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry. Nature Genetics, 41(8), 879-881. https://doi.org/10.1038/ng.416

Benjamin, EJ, Rice, KM, Arking, DE, Pfeufer, A, Van Noord, C, Smith, AV, Schnabel, RB, Bis, JC, Boerwinkle, E, Sinner, MF, Dehghan, A, Lubitz, SA, D'Agostino, RB, Lumley, T, Ehret, GB, Heeringa, J, Aspelund, T, Newton-Cheh, C, Larson, MG, Marciante, KD, Soliman, EZ, Rivadeneira, F, Wang, TJ, Eiríksdottir, G, Levy, D, Psaty, BM, Li, M, Chamberlain, AM, Hofman, A, Vasan, RS, Harris, TB, Rotter, JI, Kao, WHL, Agarwal, SK, Stricker, BHC, Wang, K, Launer, LJ, Smith, NL, Chakravarti, A, Uitterlinden, AG, Wolf, PA, Sotoodehnia, N, Köttgen, A, Van Duijn, CM, Meitinger, T, Mueller, M, Perz, S, Steinbeck, G, Wichmann, HE, Lunetta, KL, Heckbert, SR, Gudnason, V, Alonso, A, Kääb, S, Ellinor, PT & Witteman, JCM 2009, 'Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry', Nature Genetics, vol. 41, no. 8, pp. 879-881. https://doi.org/10.1038/ng.416

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title = "Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry",

abstract = "We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).",

author = "Benjamin, {Emelia J.} and Rice, {Kenneth M.} and Arking, {Dan E.} and Arne Pfeufer and {Van Noord}, Charlotte and Smith, {Albert V.} and Schnabel, {Renate B.} and Bis, {Joshua C.} and Eric Boerwinkle and Sinner, {Moritz F.} and Abbas Dehghan and Lubitz, {Steven A.} and D'Agostino, {Ralph B.} and Thomas Lumley and Ehret, {Georg B.} and Jan Heeringa and Thor Aspelund and Christopher Newton-Cheh and Larson, {Martin G.} and Marciante, {Kristin D.} and Soliman, {Elsayed Z.} and Fernando Rivadeneira and Wang, {Thomas J.} and Gudny Eir{\'i}ksdottir and Daniel Levy and Psaty, {Bruce M.} and Man Li and Chamberlain, {Alanna M.} and Albert Hofman and Vasan, {Ramachandran S.} and Harris, {Tamara B.} and Rotter, {Jerome I.} and Kao, {W. H Linda} and Agarwal, {Sunil K.} and Stricker, {Bruno H Ch} and Ke Wang and Launer, {Lenore J.} and Smith, {Nicholas L.} and Aravinda Chakravarti and Uitterlinden, {Andr{\'e} G.} and Wolf, {Philip A.} and Nona Sotoodehnia and Anna K{\"o}ttgen and {Van Duijn}, {Cornelia M.} and Thomas Meitinger and Martina Mueller and Siegfried Perz and Gerhard Steinbeck and Wichmann, {H. Erich} and Lunetta, {Kathryn L.} and Heckbert, {Susan R.} and Vilmundur Gudnason and Alvaro Alonso and Stefan K{\"a}{\"a}b and Ellinor, {Patrick T.} and Witteman, {Jacqueline C M}",

year = "2009",

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AU - Benjamin, Emelia J.

AU - Rice, Kenneth M.

AU - Arking, Dan E.

AU - Pfeufer, Arne

AU - Van Noord, Charlotte

AU - Smith, Albert V.

AU - Schnabel, Renate B.

AU - Bis, Joshua C.

AU - Boerwinkle, Eric

AU - Sinner, Moritz F.

AU - Dehghan, Abbas

AU - Lubitz, Steven A.

AU - D'Agostino, Ralph B.

AU - Lumley, Thomas

AU - Ehret, Georg B.

AU - Heeringa, Jan

AU - Aspelund, Thor

AU - Newton-Cheh, Christopher

AU - Larson, Martin G.

AU - Marciante, Kristin D.

AU - Soliman, Elsayed Z.

AU - Rivadeneira, Fernando

AU - Wang, Thomas J.

AU - Eiríksdottir, Gudny

AU - Levy, Daniel

AU - Psaty, Bruce M.

AU - Li, Man

AU - Chamberlain, Alanna M.

AU - Hofman, Albert

AU - Vasan, Ramachandran S.

AU - Harris, Tamara B.

AU - Rotter, Jerome I.

AU - Kao, W. H Linda

AU - Agarwal, Sunil K.

AU - Stricker, Bruno H Ch

AU - Wang, Ke

AU - Launer, Lenore J.

AU - Smith, Nicholas L.

AU - Chakravarti, Aravinda

AU - Uitterlinden, André G.

AU - Wolf, Philip A.

AU - Sotoodehnia, Nona

AU - Köttgen, Anna

AU - Van Duijn, Cornelia M.

AU - Meitinger, Thomas

AU - Mueller, Martina

AU - Perz, Siegfried

AU - Steinbeck, Gerhard

AU - Wichmann, H. Erich

AU - Lunetta, Kathryn L.

AU - Heckbert, Susan R.

AU - Gudnason, Vilmundur

AU - Alonso, Alvaro

AU - Kääb, Stefan

AU - Ellinor, Patrick T.

AU - Witteman, Jacqueline C M

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AB - We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 × 10-7). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 × 10 -11; combined RR = 1.25; combined P = 1.8 × 10 -15).

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JO - Nature Genetics

JF - Nature Genetics

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ER -

Variants in ZFHX3 are associated with a trial fibrillation in individuals of European ancestry

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