Abstract
We consider response-adaptive design of clinical trials under a variance-penalized criterion in the presence of mismeasurement. An explicit expression for the variance-penalized criterion with misclassified dichotomous responses is derived for response-adaptive designs and some properties are discussed. A new target proportion of treatment allocation is proposed under the criterion and related simulation results are presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2128-2135 |
| Number of pages | 8 |
| Journal | Journal of Statistical Planning and Inference |
| Volume | 142 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2012 |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors thank the anonymous referee and the Associate Editor for a number of valuable comments, which helped improving our manuscript. Xikui Wang's research is funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada .
Keywords
- Clinical trials
- Misclassification
- Power
- Response-adaptive designs
- Variance-penalized criterion
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