Variability of Night-to-day Blood Pressure Ratio from Sevenday/ 24-h Ambulatory Blood Pressure Monitoring in Healthy Subjects and in Patients with Coronary Heart Disease

The aim of the present study was to examine variability of night-to-day blood pressure ratio from seven day/24 h ambulatory blood pressure monitoring in healthy subjects and in patients with coronary heart disease. 50 healthy subjects and-50 patients with ischemic coronary heart diseases were examined. The 50 patients with coronary heart diseases were under pharmacological therapy with ACE inhibitors, beta blockers and statins. They are also treated in cardiovascular rehabilitation before the ambulatory blood pressure monitoring. The ambulatory blood pressure monitoring was in every subject and patients provided seven days/ 24 hours with the A and D Japan equipment. Mean day-time and mean night-time systolic and diastolic pressures were evaluated every day. We used also evaluation of seven day mean value of dipping of night-to-day ratio. Dipper status was evaluated every day. Dippers were defined as those individuals with a 10-20 % fall in nocturnal blood pressure (D). Non-dipping was defined as a less than 10 % nocturnal fall (ND), and those with no fall in blood pressure were defined as reverse-dippers (RD) and reverse dippers (RD) showed the reverse increase in blood pressure. Our result showed that the group of 50 healthy subjects and 50 patients with ischemic heart disease showed variability of seven day/24 h mean values of night-to-day ratio in systolic and diastolic blood pressure: Mean values from seven day/24 h of dipping status were in healthy subjects in systolic blood pressure 60%, in patients with ischemic heart disease 48%, non-dipping status were in healthy subjects 16% ED and .6% RD, in patients with ischemic heart disease non-dipping status was 16% ED. Mean value from seven day/24 h of dipping in diastolic blood pressure in heathy subjects was 44% and in patients with ischemic heart disease 62%, non-dipping in healthy subjects were 14% ND, 40% ED, in patients with ischemic heart disease 14%ND, 24%ED.