TY - JOUR
T1 - Variability in individual serum cholesterol response to change in diet
AU - Jacobs, D. R.
AU - Anderson, J. T.
AU - Hannan, P.
AU - Keys, A.
AU - Blackburn, H.
PY - 1983
Y1 - 1983
N2 - Few systematic data are available on the range of individual blood lipid responsiveness to specific diet changes. Multiple, carefully standardized total serum cholesterol (TC) measurements were made in 58 men under a variety of controlled dietary conditions. Responsiveness was defined for each individual as the change in mean TC per unit change in Diet Score based on the Keys-Minnesota equation. Only 3% were potentially 'nonresponders', and even these probably evidenced some response. Of the group, 64% responded with 30% of prediction. We classed 9% as hyporesponders, while in another 9% responsiveness exceeded 1.5 times expectation. We conclude that in metabolically normal individuals the variation in short-term response to dietary change is normally distributed but that nonresponse to diet change is rare. Because metabolic, intrinsic hyporesponsiveness of TC to change in diet composition is uncommon, assessment of the real effectiveness of a dietary regimen in an individual is best based on observed dietary changes. TC changes among individuals under treatment should be based on multiple determinations and interpreted with caution.
AB - Few systematic data are available on the range of individual blood lipid responsiveness to specific diet changes. Multiple, carefully standardized total serum cholesterol (TC) measurements were made in 58 men under a variety of controlled dietary conditions. Responsiveness was defined for each individual as the change in mean TC per unit change in Diet Score based on the Keys-Minnesota equation. Only 3% were potentially 'nonresponders', and even these probably evidenced some response. Of the group, 64% responded with 30% of prediction. We classed 9% as hyporesponders, while in another 9% responsiveness exceeded 1.5 times expectation. We conclude that in metabolically normal individuals the variation in short-term response to dietary change is normally distributed but that nonresponse to diet change is rare. Because metabolic, intrinsic hyporesponsiveness of TC to change in diet composition is uncommon, assessment of the real effectiveness of a dietary regimen in an individual is best based on observed dietary changes. TC changes among individuals under treatment should be based on multiple determinations and interpreted with caution.
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U2 - 10.1161/01.atv.3.4.349
DO - 10.1161/01.atv.3.4.349
M3 - Article
C2 - 6882289
AN - SCOPUS:0020608802
VL - 3
SP - 349
EP - 356
JO - Journal of Fluid Mechanics
JF - Journal of Fluid Mechanics
SN - 0022-1120
IS - 4
ER -