Vanadium induces AP-1- and NFκB-dependent transcription activity

Chuanshu Huang; Nanyue Chen; Wei-Ya Ma; Zigang Dong

Vanadium induces AP-1- and NFκB-dependent transcription activity

Chuanshu Huang, Nanyue Chen, Wei-Ya Ma, Zigang Dong

The Hormel Institute

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFκB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFκB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly increased at 100 μM of vanadate, while phosphorylation of JNKs was not affected. Vanadate also enhances the phosphorylation of IκBα. These results suggest that the activation of AP-1 and NFκB by vanadate may be mediated through enhancement of phosphorylation of Erk/p38 kinases and IκBα, respectively.

Original language	English (US)
Pages (from-to)	711-715
Number of pages	5
Journal	International Journal of Oncology
Volume	13
Issue number	4
State	Published - Oct 1998

Keywords

AP-1
NFκB
Vanadium

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title = "Vanadium induces AP-1- and NFκB-dependent transcription activity",

abstract = "Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFκB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFκB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly increased at 100 μM of vanadate, while phosphorylation of JNKs was not affected. Vanadate also enhances the phosphorylation of IκBα. These results suggest that the activation of AP-1 and NFκB by vanadate may be mediated through enhancement of phosphorylation of Erk/p38 kinases and IκBα, respectively.",

keywords = "AP-1, NFκB, Vanadium",

author = "Chuanshu Huang and Nanyue Chen and Wei-Ya Ma and Zigang Dong",

year = "1998",

month = oct,

language = "English (US)",

volume = "13",

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journal = "International Journal of Oncology",

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TY - JOUR

T1 - Vanadium induces AP-1- and NFκB-dependent transcription activity

AU - Huang, Chuanshu

AU - Chen, Nanyue

AU - Ma, Wei-Ya

AU - Dong, Zigang

PY - 1998/10

Y1 - 1998/10

N2 - Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFκB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFκB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly increased at 100 μM of vanadate, while phosphorylation of JNKs was not affected. Vanadate also enhances the phosphorylation of IκBα. These results suggest that the activation of AP-1 and NFκB by vanadate may be mediated through enhancement of phosphorylation of Erk/p38 kinases and IκBα, respectively.

AB - Vanadate has been reported to be involved in the causation of cancer. In this study, we found that both AP-1 and NFκB activities were increased after treatment with sodium vanadate in JB6 cells. Maximum induction of AP-1 and NFκB appeared at 48 to 72 h. Phosphorylations of Erks and p38 kinases were markedly increased at 100 μM of vanadate, while phosphorylation of JNKs was not affected. Vanadate also enhances the phosphorylation of IκBα. These results suggest that the activation of AP-1 and NFκB by vanadate may be mediated through enhancement of phosphorylation of Erk/p38 kinases and IκBα, respectively.

KW - AP-1

KW - NFκB

KW - Vanadium

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M3 - Article

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AN - SCOPUS:0031671186

SN - 1019-6439

VL - 13

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JO - International Journal of Oncology

JF - International Journal of Oncology

IS - 4

ER -

Vanadium induces AP-1- and NFκB-dependent transcription activity

Abstract

Keywords

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