TY - JOUR
T1 - Value of alkaline phosphatase, 5'-nucleotidase, γ-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver
AU - Kim, N. K.
AU - Yasmineh, W. G.
AU - Freier, E. F.
AU - Goldman, A. I.
AU - Theologides, A.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1977
Y1 - 1977
N2 - In 98 patients with cancer, the diagnostic value of measuring serum alkaline phosphatase, 5'-nucleotidase, γ-glutamyltransferase, and glutamate dehydrogenase activities were assessed as an aid to detection of liver metastases. All four enzymes showed diagnostic value, but 5'-nucleotidase appeared to have the greatest. It showed the lowest false-positive results (7.4%) with the highest predictive value of a positive test (85.7%) and agreement (81.3%). γ-Glutamyltransferase showed the lowest proportion of false-negative results (2.8%), but was the least specific (35% false-positive results). Analysis of various test combinations showed that the best agreement (77.5%) was obtained when the patients were divided into those who had no or only one abnormal test result, and those who had two or more abnormal test results. However, this was not better than the agreement for 5'-nucleotidase alone (81.3%). The agreement of 5'-nucleotidase and γ-glutamyltransferase (i.e., both tests were positive or negative) was excellent (91.4%), but such agreement included only 67% of the patients with liver metastases.
AB - In 98 patients with cancer, the diagnostic value of measuring serum alkaline phosphatase, 5'-nucleotidase, γ-glutamyltransferase, and glutamate dehydrogenase activities were assessed as an aid to detection of liver metastases. All four enzymes showed diagnostic value, but 5'-nucleotidase appeared to have the greatest. It showed the lowest false-positive results (7.4%) with the highest predictive value of a positive test (85.7%) and agreement (81.3%). γ-Glutamyltransferase showed the lowest proportion of false-negative results (2.8%), but was the least specific (35% false-positive results). Analysis of various test combinations showed that the best agreement (77.5%) was obtained when the patients were divided into those who had no or only one abnormal test result, and those who had two or more abnormal test results. However, this was not better than the agreement for 5'-nucleotidase alone (81.3%). The agreement of 5'-nucleotidase and γ-glutamyltransferase (i.e., both tests were positive or negative) was excellent (91.4%), but such agreement included only 67% of the patients with liver metastases.
UR - http://www.scopus.com/inward/record.url?scp=0017699921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017699921&partnerID=8YFLogxK
U2 - 10.1093/clinchem/23.11.2034
DO - 10.1093/clinchem/23.11.2034
M3 - Article
C2 - 21041
AN - SCOPUS:0017699921
VL - 23
SP - 2034
EP - 2038
JO - Journal of Fluid Mechanics
JF - Journal of Fluid Mechanics
SN - 0022-1120
IS - 11
ER -