Value and limitations of transpulmonary pressure calculations during intra-abdominal hypertension

Gustavo A. Cortes-Puentes, Kenneth E. Gard, Alexander B. Adams, Katherine A. Faltesek, Christopher P. Anderson, David J. Dries, John J. Marini

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Objective: To clarify the effect of progressively increasing intra-abdominal pressure on esophageal pressure, transpulmonary pressure, and functional residual capacity. Design: Controlled application of increased intra-abdominal pressure at two positive end-expiratory pressure levels (1 and 10 cm H2O) in an anesthetized porcine model of controlled ventilation. Setting: Large animal laboratory of a university-affiliated hospital. Subjects: Eleven deeply anesthetized swine (weight 46.2 ± 6.2 kg). Interventions: Air-regulated intra-abdominal hypertension (0-25 mm Hg). Measurements: Esophageal pressure, tidal compliance, bladder pressure, and end-expiratory lung aeration by gas dilution. MAIN Results: Functional residual capacity was significantly reduced by increasing intra-abdominal pressure at both positive end-expiratory pressure levels (p ≤ 0.0001) without corresponding changes of end-expiratory esophageal pressure. Above intra-abdominal pressure 5 mm Hg, plateau airway pressure increased linearly by ~ 50% of the applied intra-abdominal pressure value, associated with commensurate changes of esophageal pressure. With tidal volume held constant, negligible changes occurred in transpulmonary pressure due to intra-abdominal pressure. Driving pressures calculated from airway pressures alone (plateau airway pressure - positive end-expiratory pressure) did not equate to those computed from transpulmonary pressure (tidal changes in transpulmonary pressure). Increasing positive end-expiratory pressure shifted the predominantly negative end-expiratory transpulmonary pressure at positive end-expiratory pressure 1 cm H2O (mean -3.5 ± 0.4 cm H2O) into the positive range at positive end-expiratory pressure 10 cm H2O (mean 0.58 ± 1.2 cm H2O). Conclusions: Despite its insensitivity to changes in functional residual capacity, measuring transpulmonary pressure may be helpful in explaining how different levels of positive end-expiratory pressure influence recruitment and collapse during tidal ventilation in the presence of increased intra-abdominal pressure and in calculating true transpulmonary driving pressure (tidal changes of transpulmonary pressure). Traditional interpretations of respiratory mechanics based on unmodified airway pressure were misleading regarding lung behavior in this setting.

Original languageEnglish (US)
Pages (from-to)1870-1877
Number of pages8
JournalCritical care medicine
Volume41
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • Critical care
  • Esophageal pressure
  • Intra-abdominal hypertension
  • Mechanical ventilation
  • Positive end-expiratory pressure
  • Transpulmonary pressure

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    Cortes-Puentes, G. A., Gard, K. E., Adams, A. B., Faltesek, K. A., Anderson, C. P., Dries, D. J., & Marini, J. J. (2013). Value and limitations of transpulmonary pressure calculations during intra-abdominal hypertension. Critical care medicine, 41(8), 1870-1877. https://doi.org/10.1097/CCM.0b013e31828a3bea