Valproic acid pharmacokinetics in children: III. Very high dosage requirements

Robert L. Kriel, James H. Fischer, James C Cloyd, Kathryn H. Green, Gilles L. Fraser

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Nine children were studied who required very high doses of valproic acid (VPA) (63.6-105 mg/kg/day) in order to achieve VPA serum concentrations between 50-100 μg/ml. These nine children had poorly controlled seizures and were receiving other antiepileptic drugs at the time of this study. The children with very high dose requirements were significantly lighter, shorter, and had less body surface area than the control group. Of the pharmacokinetic parameters studied, total and intrinsic clearance, distribution volume, and valproic acid free fraction were significantly increased in the very high dose group. In three patients who were investigated after co-medications were eliminated, clearances and dosage requirements decreased by more than 50%. We concluded that very high VPA dosages are sometimes required to achieve therapeutic serum drug concentrations and that this therapy occasionally improves seizure control. There were no adverse effects of very high dose therapy that required dosage reduction.

Original languageEnglish (US)
Pages (from-to)202-208
Number of pages7
JournalPediatric Neurology
Volume2
Issue number4
DOIs
StatePublished - 1986

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Fingerprint

Dive into the research topics of 'Valproic acid pharmacokinetics in children: III. Very high dosage requirements'. Together they form a unique fingerprint.

Cite this