Abstract
Of 35 patients who had generalized tonic-clonic seizures during antiepileptic drug therapy withdrawal,“loading” with valproic acid was effective in limiting these seizures in 32 patients. A loading dose of approximately 12.5 mg/kg was used. This dose resulted in valproic acid levels between 284 and 458 μmol/L (41 and 66 mg/L) 1.5 hours after“loading” in six of the eight patients in whom serum concentrations were measured.
Original language | English (US) |
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Pages (from-to) | 709-710 |
Number of pages | 2 |
Journal | Archives of Neurology |
Volume | 44 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1987 |