Valproic Acid Loading During Intensive Monitoring

William E. Rosenfeld, Ilo E. Leppik, John R. Gates, Ruy E. Mireles

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Of 35 patients who had generalized tonic-clonic seizures during antiepileptic drug therapy withdrawal,“loading” with valproic acid was effective in limiting these seizures in 32 patients. A loading dose of approximately 12.5 mg/kg was used. This dose resulted in valproic acid levels between 284 and 458 μmol/L (41 and 66 mg/L) 1.5 hours after“loading” in six of the eight patients in whom serum concentrations were measured.

Original languageEnglish (US)
Pages (from-to)709-710
Number of pages2
JournalArchives of Neurology
Issue number7
StatePublished - Jul 1987


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