Abstract
This chapter begins by discussing the validity of the drug and diagnostic information used by clinicians in patients’ care. Next, it discusses measurement error, describing the different types of error and error detection methods, exploring how errors may affect the point estimate, and describing current techniques for mitigation. The chapter illustrates validity concerns when data from administrative claims, electronic health records, or questionnaire responses are used, using as examples studies of the associations between nonsteroidal anti‐inflammatory drugs (NSAIDs) and myocardial infarction, and between NSAIDs and gastrointestinal bleeding. Besides self‐reported data, pharmacoepidemiologists have been using administrative claims data for more than 30 years to evaluate drug safety. The chapter discusses validity issues with using these data for research. However, the changing landscape of health care requires reassessing the validity of the data pharmacoepidemiologists are now using for their research and how these data impact clinical practice.
| Original language | English (US) |
|---|---|
| Title of host publication | Textbook of Pharmacoepidemiology, Third Edition |
| Publisher | Wiley |
| Pages | 221-245 |
| Number of pages | 25 |
| ISBN (Electronic) | 9781119701101 |
| ISBN (Print) | 9781119701088 |
| DOIs | |
| State | Published - Jan 1 2021 |
Bibliographical note
Publisher Copyright:© 2022 John Wiley & Sons Ltd.
Keywords
- diagnostic information
- nonsteroidal anti‐inflammatory drugs
- pharmacoepidemiologic research
- pharmacoepidemiologists
- validity issues